Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2180758..2181229 | Replicon | chromosome |
| Accession | NZ_CP059279 | ||
| Organism | Escherichia coli strain C7 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | H0271_RS10420 | Protein ID | WP_001303511.1 |
| Coordinates | 2180758..2181036 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | H0271_RS10425 | Protein ID | WP_001302048.1 |
| Coordinates | 2181038..2181229 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H0271_RS10385 | 2175971..2176240 | - | 270 | WP_000003742.1 | excisionase | - |
| H0271_RS10390 | 2176302..2178740 | - | 2439 | WP_000102132.1 | exonuclease | - |
| H0271_RS10395 | 2178833..2179021 | - | 189 | WP_000199475.1 | DUF1482 family protein | - |
| H0271_RS10400 | 2179018..2179206 | - | 189 | WP_000449175.1 | cell division inhibitor | - |
| H0271_RS10405 | 2179782..2179976 | + | 195 | WP_001295058.1 | hypothetical protein | - |
| H0271_RS10410 | 2179965..2180303 | - | 339 | WP_000394541.1 | hypothetical protein | - |
| H0271_RS10415 | 2180315..2180467 | - | 153 | WP_000380313.1 | DUF1391 family protein | - |
| H0271_RS10420 | 2180758..2181036 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| H0271_RS10425 | 2181038..2181229 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| H0271_RS10430 | 2181250..2181621 | - | 372 | WP_001169687.1 | hypothetical protein | - |
| H0271_RS10435 | 2181719..2182021 | + | 303 | WP_001556930.1 | transcriptional regulator | - |
| H0271_RS10440 | 2182018..2182443 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| H0271_RS10445 | 2182466..2183428 | + | 963 | WP_000095673.1 | helix-turn-helix domain-containing protein | - |
| H0271_RS10450 | 2183435..2184181 | + | 747 | WP_000788950.1 | ATP-binding protein | - |
| H0271_RS10455 | 2184203..2184973 | + | 771 | WP_000450998.1 | DUF1627 domain-containing protein | - |
| H0271_RS10460 | 2184989..2185411 | + | 423 | Protein_2028 | DUF977 family protein | - |
| H0271_RS10465 | 2185517..2185729 | + | 213 | WP_000072553.1 | hypothetical protein | - |
| H0271_RS10470 | 2185762..2185980 | + | 219 | WP_001610644.1 | DUF4014 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2172361..2199614 | 27253 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T168434 WP_001303511.1 NZ_CP059279:c2181036-2180758 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T168434 NZ_CP075889:8835187-8835537 [Paenibacillus agaridevorans]
TTGATCGTCAAACGCGGAGATGTTTTTTTTGCCGATTTGTCCCCAGTCGTAGGATCTGAACAGGGAGGAGTCCGTCCCGT
TCTCGTAATACAGAATGACATCGGTAACCGCTTCAGCCCTACCGTCATCGTAGCTGCCATCACCGCTCAAATTCAGAAAG
CAAAGTTGCCGACGCATGTAGAGATGGATGCGGCGACGCATGGCTTCGACCGCGATTCCGTCGTGCTGCTGGAGCAGATC
CGTACGATCGACAAGCAGCGTCTGACGGACAAAATTACGCATCTGGACGACGAAACGATGCGAAAGGTCGACGATGCGCT
GTTGATTAGCGTCGGTTTGATCGATTTCTAA
TTGATCGTCAAACGCGGAGATGTTTTTTTTGCCGATTTGTCCCCAGTCGTAGGATCTGAACAGGGAGGAGTCCGTCCCGT
TCTCGTAATACAGAATGACATCGGTAACCGCTTCAGCCCTACCGTCATCGTAGCTGCCATCACCGCTCAAATTCAGAAAG
CAAAGTTGCCGACGCATGTAGAGATGGATGCGGCGACGCATGGCTTCGACCGCGATTCCGTCGTGCTGCTGGAGCAGATC
CGTACGATCGACAAGCAGCGTCTGACGGACAAAATTACGCATCTGGACGACGAAACGATGCGAAAGGTCGACGATGCGCT
GTTGATTAGCGTCGGTTTGATCGATTTCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT168434 WP_001302048.1 NZ_CP059279:c2181229-2181038 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT168434 NZ_CP075889:8834902-8835183 [Paenibacillus agaridevorans]
GTGGCCAATATCCATAATACGAAAAGGATCATGATCAGCCTGCCCGATCAGCTGCTGGAGGAAGTCGACGGAATCGTCGC
CAAGGAAAACTCCAATCGCAGCGAGTTTATTCGGCAAGCCATGAAGCTGTATCTGGTAGAGCGCAAGAAACGTCAAATCC
GCGAGTCCATGCAGCGCGGCTATATGGAGATGGCGAGAATCAATCTGAACATGGCCTCGGAAGCGTTTCAAGCAGAGGAA
GAAGCGGATCACACGTTAGGGCGTCTAGTGAGCGGGGTGTAG
GTGGCCAATATCCATAATACGAAAAGGATCATGATCAGCCTGCCCGATCAGCTGCTGGAGGAAGTCGACGGAATCGTCGC
CAAGGAAAACTCCAATCGCAGCGAGTTTATTCGGCAAGCCATGAAGCTGTATCTGGTAGAGCGCAAGAAACGTCAAATCC
GCGAGTCCATGCAGCGCGGCTATATGGAGATGGCGAGAATCAATCTGAACATGGCCTCGGAAGCGTTTCAAGCAGAGGAA
GAAGCGGATCACACGTTAGGGCGTCTAGTGAGCGGGGTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|