Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1511625..1512243 Replicon chromosome
Accession NZ_CP059279
Organism Escherichia coli strain C7

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag H0271_RS07225 Protein ID WP_001291435.1
Coordinates 1511625..1511843 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag H0271_RS07230 Protein ID WP_000344800.1
Coordinates 1511869..1512243 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0271_RS07190 1506913..1507485 + 573 WP_000779841.1 YbaY family lipoprotein -
H0271_RS07195 1507516..1507827 - 312 WP_000409908.1 MGMT family protein -
H0271_RS07205 1508206..1508559 + 354 WP_000878147.1 DUF1428 family protein -
H0271_RS07210 1508601..1510151 - 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
H0271_RS07215 1510315..1510785 - 471 WP_000136192.1 YlaC family protein -
H0271_RS07220 1510901..1511452 - 552 WP_000102539.1 maltose O-acetyltransferase -
H0271_RS07225 1511625..1511843 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
H0271_RS07230 1511869..1512243 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
H0271_RS07235 1512789..1515938 - 3150 WP_001132478.1 multidrug efflux RND transporter permease subunit -
H0271_RS07240 1515961..1517154 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T168432 WP_001291435.1 NZ_CP059279:c1511843-1511625 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T168432 NZ_CP075885:3470306-3470408 [Klebsiella quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT168432 WP_000344800.1 NZ_CP059279:c1512243-1511869 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT168432 NZ_CP075885:c3470412-3470265 [Klebsiella quasipneumoniae]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References