Detailed information of TA system TA168428

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 946050..946870
• Replicon: chromosome
• Accession: NZ_CP059279
• Organism: Escherichia coli strain C7

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: H0271_RS04415
• Protein ID: WP_001054379.1
• Coordinates: 946613..946870 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: H0271_RS04410
• Protein ID: WP_000123957.1
• Coordinates: 946050..946601 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0271_RS04385	941744..943057	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
H0271_RS04390	943069..943347	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
H0271_RS04395	943344..944465	-	1122	WP_000010833.1	M42 family metallopeptidase	-
H0271_RS04400	944864..945124	-	261	WP_000077645.1	hypothetical protein	-
H0271_RS04405	945252..945998	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
H0271_RS04410	946050..946601	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
H0271_RS04415	946613..946870	-	258	WP_001054379.1	YjhX family toxin	Toxin
H0271_RS04420	947247..947546	-	300	WP_001332034.1	GNAT family N-acetyltransferase	-
H0271_RS04425	947624..948355	+	732	Protein_851	DNA helicase	-
H0271_RS04430	948385..949998	-	1614	WP_000080195.1	IS66-like element ISEc23 family transposase	-
H0271_RS04435	950029..950379	-	351	WP_000624722.1	IS66 family insertion sequence element accessory protein TnpB	-
H0271_RS04440	950376..950801	-	426	WP_000422741.1	IS66 family insertion sequence hypothetical protein	-
H0271_RS04445	950929..951390	+	462	WP_012896898.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T168428 WP_001054379.1 NZ_CP059279:c946870-946613 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T168428 NZ_CP075884:14413-14895 [Klebsiella quasipneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGCAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT168428 WP_000123957.1 NZ_CP059279:c946601-946050 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT168428 NZ_CP075884:14159-14425 [Klebsiella quasipneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Toxin

• AlphaFold DB: B6I030