Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 120217..121049 | Replicon | chromosome |
Accession | NZ_CP059279 | ||
Organism | Escherichia coli strain C7 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | E3PN67 |
Locus tag | H0271_RS00585 | Protein ID | WP_000854775.1 |
Coordinates | 120675..121049 (+) | Length | 125 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | A0A426P7N5 |
Locus tag | H0271_RS00580 | Protein ID | WP_001285645.1 |
Coordinates | 120217..120585 (+) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H0271_RS00545 | 116040..116720 | + | 681 | WP_001282911.1 | WYL domain-containing protein | - |
H0271_RS00550 | 116871..117548 | + | 678 | WP_001097567.1 | hypothetical protein | - |
H0271_RS00555 | 117554..117787 | + | 234 | WP_001278284.1 | DUF905 family protein | - |
H0271_RS00560 | 117877..118695 | + | 819 | WP_001175173.1 | DUF945 domain-containing protein | - |
H0271_RS00565 | 118787..119272 | + | 486 | WP_000213721.1 | antirestriction protein | - |
H0271_RS00570 | 119288..119764 | + | 477 | WP_001318130.1 | RadC family protein | - |
H0271_RS00575 | 119833..120054 | + | 222 | WP_000692303.1 | DUF987 domain-containing protein | - |
H0271_RS00580 | 120217..120585 | + | 369 | WP_001285645.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
H0271_RS00585 | 120675..121049 | + | 375 | WP_000854775.1 | TA system toxin CbtA family protein | Toxin |
H0271_RS00590 | 121046..121537 | + | 492 | WP_000976825.1 | hypothetical protein | - |
H0271_RS00595 | 121549..121746 | + | 198 | WP_000772035.1 | DUF957 domain-containing protein | - |
H0271_RS00600 | 121831..122673 | + | 843 | WP_001274548.1 | DUF4942 domain-containing protein | - |
H0271_RS00605 | 123269..123766 | + | 498 | WP_000509815.1 | hypothetical protein | - |
H0271_RS00610 | 123944..124867 | + | 924 | WP_000535950.1 | carboxylate/amino acid/amine transporter | - |
H0271_RS00615 | 124871..125689 | - | 819 | WP_000779409.1 | lipoprotein NlpA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13965.02 Da Isoelectric Point: 8.2830
>T168425 WP_000854775.1 NZ_CP059279:120675-121049 [Escherichia coli]
MKTLPDTLVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK
MKTLPDTLVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK
Download Length: 375 bp
>T168425 NZ_CP075882:c36060-35635 [Klebsiella michiganensis]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTGGCTTTGTTGAATAA
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTGGCTTTGTTGAATAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13678.37 Da Isoelectric Point: 5.4492
>AT168425 WP_001285645.1 NZ_CP059279:120217-120585 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTNG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTNG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT168425 NZ_CP075882:c36287-36057 [Klebsiella michiganensis]
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | E3PN67 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A426P7N5 |