Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 120217..121049 Replicon chromosome
Accession NZ_CP059279
Organism Escherichia coli strain C7

Toxin (Protein)


Gene name yeeV Uniprot ID E3PN67
Locus tag H0271_RS00585 Protein ID WP_000854775.1
Coordinates 120675..121049 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A426P7N5
Locus tag H0271_RS00580 Protein ID WP_001285645.1
Coordinates 120217..120585 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0271_RS00545 116040..116720 + 681 WP_001282911.1 WYL domain-containing protein -
H0271_RS00550 116871..117548 + 678 WP_001097567.1 hypothetical protein -
H0271_RS00555 117554..117787 + 234 WP_001278284.1 DUF905 family protein -
H0271_RS00560 117877..118695 + 819 WP_001175173.1 DUF945 domain-containing protein -
H0271_RS00565 118787..119272 + 486 WP_000213721.1 antirestriction protein -
H0271_RS00570 119288..119764 + 477 WP_001318130.1 RadC family protein -
H0271_RS00575 119833..120054 + 222 WP_000692303.1 DUF987 domain-containing protein -
H0271_RS00580 120217..120585 + 369 WP_001285645.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H0271_RS00585 120675..121049 + 375 WP_000854775.1 TA system toxin CbtA family protein Toxin
H0271_RS00590 121046..121537 + 492 WP_000976825.1 hypothetical protein -
H0271_RS00595 121549..121746 + 198 WP_000772035.1 DUF957 domain-containing protein -
H0271_RS00600 121831..122673 + 843 WP_001274548.1 DUF4942 domain-containing protein -
H0271_RS00605 123269..123766 + 498 WP_000509815.1 hypothetical protein -
H0271_RS00610 123944..124867 + 924 WP_000535950.1 carboxylate/amino acid/amine transporter -
H0271_RS00615 124871..125689 - 819 WP_000779409.1 lipoprotein NlpA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13965.02 Da        Isoelectric Point: 8.2830

>T168425 WP_000854775.1 NZ_CP059279:120675-121049 [Escherichia coli]
MKTLPDTLVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T168425 NZ_CP075882:c36060-35635 [Klebsiella michiganensis]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTGGCTTTGTTGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13678.37 Da        Isoelectric Point: 5.4492

>AT168425 WP_001285645.1 NZ_CP059279:120217-120585 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTNG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT168425 NZ_CP075882:c36287-36057 [Klebsiella michiganensis]
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB E3PN67


Antitoxin

Source ID Structure
AlphaFold DB A0A426P7N5

References