Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1853193..1853969 Replicon chromosome
Accession NZ_CP059180
Organism Staphylococcus aureus strain SH1000

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag SAURSH1000_RS08900 Protein ID WP_000031108.1
Coordinates 1853193..1853345 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag SAURSH1000_RS08905 Protein ID WP_001251224.1
Coordinates 1853370..1853969 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAURSH1000_RS08885 (SAURSH1000_001775) 1849156..1849977 + 822 WP_000669376.1 RluA family pseudouridine synthase -
SAURSH1000_RS08890 (SAURSH1000_001776) 1850440..1851825 - 1386 WP_000116224.1 class II fumarate hydratase -
SAURSH1000_RS08895 (SAURSH1000_001777) 1852021..1852416 - 396 WP_000901021.1 hypothetical protein -
SAURSH1000_RS08900 (SAURSH1000_001778) 1853193..1853345 - 153 WP_000031108.1 SAS053 family protein Toxin
SAURSH1000_RS08905 (SAURSH1000_001779) 1853370..1853969 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
SAURSH1000_RS08910 (SAURSH1000_001780) 1854128..1854598 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
SAURSH1000_RS08915 (SAURSH1000_001781) 1854603..1855730 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
SAURSH1000_RS08920 (SAURSH1000_001782) 1855881..1856603 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
SAURSH1000_RS08925 (SAURSH1000_001783) 1856596..1858053 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T168417 WP_000031108.1 NZ_CP059180:c1853345-1853193 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T168417 NZ_CP075881:1118963-1119304 [Klebsiella michiganensis]
ATGTGGGATGTTGAAACAACGGAGGTTTTTGACAAGTGGTTTGAGGCGCAGACCGAAGCGCTCAAAGAGGATATGCTCGC
CGCAATGGTGATCTTATCCGAGTATGGCCCCCGGTTGGGAAGGCCGTTTGCGGATACAGTAAACGATTCTGCCTTTTCGA
ATATGAAAGAGCTGCGCATTCAGCATCAAGGTAGACCCATCCGAGCTTTCTTTGTATTTGACCCTTCTCGTTGTGGCATC
GTGTTATGCGCCGGAGATAAAACAGGGTTAAATGAAAAGAGATTCTATAAAGATATGATCAAGCTTGCAGATGCTGAGTA
CCGTAAGCACCTTAATCAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT168417 WP_001251224.1 NZ_CP059180:c1853969-1853370 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT168417 NZ_CP075881:1119314-1119613 [Klebsiella michiganensis]
ATGGCGACCCTTAAAGAATTAATGGCCAAACAGAGCCCGGAAAGCCAGGCGCGTATTGCTGAAAAAGTCGAGGAGATGCG
CCAGGCTATCGCTTTAAGTATGTTAAGGGAAGAACTCAATATGTCTCAGGCAGAGCTGGCTAAGGCAATGGGTGTTAAAC
AACCCACCATAGCAAAAATGGAACAGGCTGATAACGACCCGCGTTTGTCAACGCTGAAGCGCTATGTTGCAGCGCTCGGG
GGGGAACTCAGTATTGATGTTAAGCTGCCAACCGGTAAGCGAATCGCATTCCATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References