Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 811756..812233 Replicon chromosome
Accession NZ_CP059180
Organism Staphylococcus aureus strain SH1000

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag SAURSH1000_RS03880 Protein ID WP_000052078.1
Coordinates 811756..811944 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAURSH1000_RS03885 Protein ID WP_001059690.1
Coordinates 811973..812233 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAURSH1000_RS03850 (SAURSH1000_000769) 807797..808267 + 471 WP_000824472.1 hypothetical protein -
SAURSH1000_RS03855 (SAURSH1000_000770) 808608..809294 + 687 WP_001548082.1 thermonuclease family protein -
SAURSH1000_RS03860 (SAURSH1000_000771) 809651..809851 + 201 WP_001059082.1 cold-shock protein -
SAURSH1000_RS03865 (SAURSH1000_000772) 810347..810565 - 219 WP_000005886.1 hypothetical protein -
SAURSH1000_RS03870 (SAURSH1000_000773) 810627..810911 - 285 WP_001004395.1 hypothetical protein -
SAURSH1000_RS03875 (SAURSH1000_000774) 810999..811568 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
SAURSH1000_RS03880 (SAURSH1000_000775) 811756..811944 - 189 WP_000052078.1 hypothetical protein Toxin
SAURSH1000_RS03885 (SAURSH1000_000776) 811973..812233 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAURSH1000_RS03890 (SAURSH1000_000777) 812574..812777 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAURSH1000_RS03895 (SAURSH1000_000778) 812774..813010 - 237 WP_000368687.1 hypothetical protein -
SAURSH1000_RS03900 (SAURSH1000_000779) 813235..813816 + 582 WP_001140693.1 histidine phosphatase family protein -
SAURSH1000_RS03905 (SAURSH1000_000780) 813889..814506 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
SAURSH1000_RS03910 (SAURSH1000_000781) 814661..815155 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAURSH1000_RS03915 (SAURSH1000_000782) 815554..815976 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SAURSH1000_RS03920 (SAURSH1000_000783) 816124..816840 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-105)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T168414 WP_000052078.1 NZ_CP059180:c811944-811756 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T168414 NZ_CP075872:2162949-2163290 [Listeria monocytogenes]
ATGGTAAAGCAAGGCGATATTATCAAGATCAATCTAAATCCAAAACAGGGACACGAGCAGCAAGGCTATCGGCCCTATAT
TTGCCTCAGTCATCATCTGGTAAGTGATTATGCAAATATCGCGATCTTTGCCCCAATCAGTAATACACCGCGCACCTATC
CGTTATATGTGCCTTTGACAGGGACAACCACAACCGGAAAAGTATTGCTGGATCAACTAGTTACGATCGATTACAACGCT
CGTAAGCATCAATACGTGGAAACTGTTTCGGATCCATTGCTCACAAAGCTATTAGATACAGTAAAAGTTATTTTTCAAAA
GAACGAGAGATCAACCAACTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT168414 WP_001059690.1 NZ_CP059180:c812233-811973 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT168414 NZ_CP075872:2162713-2162955 [Listeria monocytogenes]
ATGACCACCGTTAGCGTTAAAAAGTGGGGAAATAGCAAAGCTGTTCGTCTCCCCAATAATCTATTAAATGCCTTAGACAT
CAAAGAGAACGATGATTTGAAAGTGGAAGTGATCAATAATCAGATGATCCTTACCAAAACAGCTATCGATCTCCGAATCG
AGGATCTGTTTGCCAATTACCAGGGCGAACCCTTCCAAACTGAGCTGCAAACATTCGAACCAATCGGAGATGAAAAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References