Detailed information of TA system TA168411

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2958097..2958616
• Replicon: chromosome
• Accession: NZ_CP059162
• Organism: Pseudomonas chlororaphis subsp. aurantiaca strain YS05

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H0I86_RS13635
• Protein ID: WP_180925419.1
• Coordinates: 2958335..2958616 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1H3UB71
• Locus tag: H0I86_RS13630
• Protein ID: WP_009044432.1
• Coordinates: 2958097..2958345 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0I86_RS13610	2953239..2954996	-	1758	WP_180925840.1	hypothetical protein	-
H0I86_RS13615	2955314..2956102	+	789	WP_180925418.1	hypothetical protein	-
H0I86_RS13620	2956129..2957127	-	999	WP_124348674.1	bile acid:sodium symporter	-
H0I86_RS13625	2957212..2958000	+	789	WP_124299848.1	helix-turn-helix transcriptional regulator	-
H0I86_RS13630	2958097..2958345	+	249	WP_009044432.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
H0I86_RS13635	2958335..2958616	+	282	WP_180925419.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H0I86_RS13640	2958800..2960449	-	1650	WP_180925420.1	FMN-binding glutamate synthase family protein	-
H0I86_RS13645	2960506..2960988	-	483	WP_009049637.1	acyl-CoA thioesterase	-
H0I86_RS13650	2961305..2962096	-	792	WP_063431768.1	methyltransferase domain-containing protein	-
H0I86_RS13655	2962178..2962395	+	218	Protein_2688	ATP-binding protein	-
H0I86_RS13660	2963037..2963309	-	273	WP_009049634.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10862.68 Da
• Isoelectric Point: 10.6993

>T168411 WP_180925419.1 NZ_CP059162:2958335-2958616 [Pseudomonas chlororaphis subsp. aurantiaca]
MTYELEFSEKAWKEWQKLGPTLKEQFKKKLQERLVNPHVPADRLSGLGNAYKIKLRTAGYRLVYRVVDEVLVVTAIAVGK
RERGSVYQQARKR

Nucleotide

• Length: 282 bp

>T168411 NZ_CP075853:53746-54144 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATGAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8997.37 Da
• Isoelectric Point: 4.4142

>AT168411 WP_009044432.1 NZ_CP059162:2958097-2958345 [Pseudomonas chlororaphis subsp. aurantiaca]
MTHVLLSNVVASISELKKNPMGTVAAGGGSSVAILNRNEPAFYCVPAKEYEAMMERLEDMELLALCRERENDPTIKVSLD
DL

Nucleotide

• Length: 249 bp

>AT168411 NZ_CP075853:53519-53746 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1H3UB71