Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2371903..2372488 Replicon chromosome
Accession NZ_CP059162
Organism Pseudomonas chlororaphis subsp. aurantiaca strain YS05

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag H0I86_RS11105 Protein ID WP_180925025.1
Coordinates 2372195..2372488 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A3G7ICX6
Locus tag H0I86_RS11100 Protein ID WP_038580367.1
Coordinates 2371903..2372193 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0I86_RS11090 2369415..2370797 + 1383 WP_180925023.1 efflux transporter outer membrane subunit -
H0I86_RS11095 2370916..2371503 + 588 WP_180925024.1 hypothetical protein -
H0I86_RS11100 2371903..2372193 - 291 WP_038580367.1 putative addiction module antidote protein Antitoxin
H0I86_RS11105 2372195..2372488 - 294 WP_180925025.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H0I86_RS11110 2372723..2374117 - 1395 WP_180925026.1 VOC family protein -
H0I86_RS11115 2374382..2375506 + 1125 WP_180925027.1 diguanylate cyclase -
H0I86_RS11120 2375596..2376840 + 1245 WP_180925028.1 M20/M25/M40 family metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(8-94)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10656.26 Da        Isoelectric Point: 9.1615

>T168410 WP_180925025.1 NZ_CP059162:c2372488-2372195 [Pseudomonas chlororaphis subsp. aurantiaca]
MDYEILQTTVFAQWHTTLRDLRARIAIARRIERASAGNLGDVKNLGGGLPEMCVNTGAGYRLYFTVRGNTLIVLLLGGDK
SSQPADICQARSLAKEF

Download         Length: 294 bp

>T168410 NZ_CP075853:c44793-44644 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10239.78 Da        Isoelectric Point: 8.0096

>AT168410 WP_038580367.1 NZ_CP059162:c2372193-2371903 [Pseudomonas chlororaphis subsp. aurantiaca]
MSDTLVPFDIAALLDSDQAISEYLSQVLADGDTDELIRALGHVARARGMTQIAKTTGQGRASLYKAFAPGAKPRFDTVVK
VMRALGLQLCTTVSRG

Download         Length: 291 bp

>AT168410 NZ_CP075853:44837-44898 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3G7ICX6

References