Detailed information of TA system TA168409

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2352649..2353268
• Replicon: chromosome
• Accession: NZ_CP059162
• Organism: Pseudomonas chlororaphis subsp. aurantiaca strain YS05

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: H0I86_RS11020
• Protein ID: WP_180925012.1
• Coordinates: 2353086..2353268 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: H0I86_RS11015
• Protein ID: WP_103330829.1
• Coordinates: 2352649..2353050 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0I86_RS11000	2348821..2350710	+	1890	WP_180925010.1	PAS domain S-box protein	-
H0I86_RS11005	2350707..2351342	+	636	WP_053260452.1	response regulator transcription factor	-
H0I86_RS11010	2351436..2352200	+	765	WP_180925011.1	hypothetical protein	-
H0I86_RS11015	2352649..2353050	-	402	WP_103330829.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H0I86_RS11020	2353086..2353268	-	183	WP_180925012.1	type II toxin-antitoxin system HicA family toxin	Toxin
H0I86_RS11025	2353612..2353893	-	282	WP_009048156.1	hypothetical protein	-
H0I86_RS11030	2354313..2354669	-	357	WP_037004592.1	hypothetical protein	-
H0I86_RS11035	2354654..2355436	-	783	WP_180925013.1	hypothetical protein	-
H0I86_RS11040	2355447..2355992	-	546	WP_124313179.1	PAAR domain-containing protein	-
H0I86_RS11045	2356288..2356836	-	549	WP_180925014.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2347016..2355992	8976

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6830.01 Da
• Isoelectric Point: 10.9678

>T168409 WP_180925012.1 NZ_CP059162:c2353268-2353086 [Pseudomonas chlororaphis subsp. aurantiaca]
VQSRQLIKELEATGWVLERVTGSHHLFKHPYRPETVPVPHPKKDLPRGTVRAIQKLAGLI

Nucleotide

• Length: 183 bp

>T168409 NZ_CP075852:4844099-4844202 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14565.51 Da
• Isoelectric Point: 4.5918

>AT168409 WP_103330829.1 NZ_CP059162:c2353050-2352649 [Pseudomonas chlororaphis subsp. aurantiaca]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELARDGQAIPLPSPTGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Nucleotide

• Length: 402 bp

>AT168409 NZ_CP075852:c4844240-4843969 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT