168401

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2199577..2200091 Replicon chromosome
Accession NZ_CP059156
Organism Staphylococcus aureus strain WKZ-1

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag HTZ90_RS10895 Protein ID WP_000581791.1
Coordinates 2199577..2199786 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag HTZ90_RS10900 Protein ID WP_000138934.1
Coordinates 2199798..2200091 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HTZ90_RS10875 2195466..2196536 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
HTZ90_RS10880 2196854..2198056 + 1203 WP_180821687.1 rod shape-determining protein RodA -
HTZ90_RS10885 2198217..2198900 - 684 Protein_2107 transposase -
HTZ90_RS10890 2199312..2199449 - 138 WP_000828354.1 hypothetical protein -
HTZ90_RS10895 2199577..2199786 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
HTZ90_RS10900 2199798..2200091 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
HTZ90_RS10905 2200257..2201741 + 1485 WP_000571560.1 cardiolipin synthase -
HTZ90_RS10910 2201769..2202416 + 648 WP_001187612.1 HD domain-containing protein -
HTZ90_RS10915 2203029..2203901 - 873 WP_000725802.1 membrane protein insertase YidC -
HTZ90_RS10920 2203987..2204628 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T168401 WP_000581791.1 NZ_CP059156:c2199786-2199577 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T168401 NZ_CP075852:3036743-3036973 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT168401 WP_000138934.1 NZ_CP059156:c2200091-2199798 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT168401 NZ_CP075852:3036970-3037329 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References