Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 847404..847881 Replicon chromosome
Accession NZ_CP059156
Organism Staphylococcus aureus strain WKZ-1

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag HTZ90_RS04000 Protein ID WP_000052076.1
Coordinates 847404..847592 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HTZ90_RS04005 Protein ID WP_001059690.1
Coordinates 847621..847881 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HTZ90_RS03970 843357..843914 + 558 WP_000824491.1 hypothetical protein -
HTZ90_RS03975 844255..844941 + 687 WP_001574556.1 thermonuclease family protein -
HTZ90_RS03980 845298..845498 + 201 WP_001059082.1 cold-shock protein -
HTZ90_RS03985 845995..846213 - 219 WP_000005879.1 hypothetical protein -
HTZ90_RS03990 846275..846559 - 285 WP_001004401.1 hypothetical protein -
HTZ90_RS03995 846647..847216 - 570 WP_001106663.1 hypothetical protein -
HTZ90_RS04000 847404..847592 - 189 WP_000052076.1 hypothetical protein Toxin
HTZ90_RS04005 847621..847881 - 261 WP_001059690.1 hypothetical protein Antitoxin
HTZ90_RS04010 848222..848425 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HTZ90_RS04015 848422..848658 - 237 WP_000368687.1 hypothetical protein -
HTZ90_RS04020 848883..849464 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
HTZ90_RS04025 849537..850154 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
HTZ90_RS04030 850311..850805 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
HTZ90_RS04035 851204..851626 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
HTZ90_RS04040 851774..852490 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T168388 WP_000052076.1 NZ_CP059156:c847592-847404 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T168388 NZ_CP075852:c225379-225203 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT168388 WP_001059690.1 NZ_CP059156:c847881-847621 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT168388 NZ_CP075852:c225157-224741 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References