Detailed information of TA system TA168387

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 359824..360356
• Replicon: chromosome
• Accession: NZ_CP059156
• Organism: Staphylococcus aureus strain WKZ-1

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: HTZ90_RS01580
• Protein ID: WP_123090134.1
• Coordinates: 360036..360356 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IA75
• Locus tag: HTZ90_RS01575
• Protein ID: WP_001058492.1
• Coordinates: 359824..360033 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HTZ90_RS01535	354928..355431	+	504	WP_000934799.1	single-stranded DNA-binding protein	-
HTZ90_RS01540	355483..355725	+	243	WP_000897044.1	30S ribosomal protein S18	-
HTZ90_RS01545	355957..356790	-	834	WP_180372434.1	type II toxin-antitoxin system PemK/MazF family toxin	-
HTZ90_RS01550	356791..358005	-	1215	WP_123090135.1	site-specific integrase	-
HTZ90_RS01555	358304..359038	-	735	WP_000142630.1	helix-turn-helix domain-containing protein	-
HTZ90_RS01560	359188..359400	+	213	WP_053040300.1	helix-turn-helix transcriptional regulator	-
HTZ90_RS01565	359401..359673	+	273	WP_053040301.1	helix-turn-helix domain-containing protein	-
HTZ90_RS01570	359685..359831	+	147	WP_000784885.1	hypothetical protein	-
HTZ90_RS01575	359824..360033	+	210	WP_001058492.1	hypothetical protein	Antitoxin
HTZ90_RS01580	360036..360356	+	321	WP_123090134.1	DUF1474 family protein	Toxin
HTZ90_RS01585	360420..361289	+	870	WP_053040303.1	primase alpha helix C-terminal domain-containing protein	-
HTZ90_RS01590	361306..362775	+	1470	WP_180821714.1	virulence-associated E family protein	-
HTZ90_RS01595	363054..363416	+	363	WP_001039165.1	hypothetical protein	-
HTZ90_RS01600	363418..363681	+	264	WP_001804819.1	hypothetical protein	-
HTZ90_RS01605	363683..364324	+	642	WP_160187057.1	pathogenicity island protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	355957..374996	19039

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12636.18 Da
• Isoelectric Point: 4.8637

>T168387 WP_123090134.1 NZ_CP059156:360036-360356 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEGRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T168387 NZ_CP075852:136136-137458 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8238.28 Da
• Isoelectric Point: 4.3718

>AT168387 WP_001058492.1 NZ_CP059156:359824-360033 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT168387 NZ_CP075852:135870-136136 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: X5IA75