Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2223826..2224340 Replicon chromosome
Accession NZ_CP059155
Organism Staphylococcus aureus strain WKZ-2

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag HTZ91_RS11015 Protein ID WP_000581791.1
Coordinates 2223826..2224035 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag HTZ91_RS11020 Protein ID WP_000138934.1
Coordinates 2224047..2224340 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HTZ91_RS10995 2219715..2220785 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
HTZ91_RS11000 2221103..2222305 + 1203 WP_180821687.1 rod shape-determining protein RodA -
HTZ91_RS11005 2222466..2223149 - 684 Protein_2131 transposase -
HTZ91_RS11010 2223561..2223698 - 138 WP_000828354.1 hypothetical protein -
HTZ91_RS11015 2223826..2224035 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
HTZ91_RS11020 2224047..2224340 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
HTZ91_RS11025 2224506..2225990 + 1485 WP_000571560.1 cardiolipin synthase -
HTZ91_RS11030 2226018..2226665 + 648 WP_001187612.1 HD domain-containing protein -
HTZ91_RS11035 2226822..2227121 + 300 WP_001793952.1 hypothetical protein -
HTZ91_RS11040 2227278..2228150 - 873 WP_000725802.1 membrane protein insertase YidC -
HTZ91_RS11045 2228236..2228877 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T168381 WP_000581791.1 NZ_CP059155:c2224035-2223826 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T168381 NZ_CP075737:c4227388-4227170 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT168381 WP_000138934.1 NZ_CP059155:c2224340-2224047 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT168381 NZ_CP075737:c4227788-4227414 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References