Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 871652..872129 Replicon chromosome
Accession NZ_CP059155
Organism Staphylococcus aureus strain WKZ-2

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag HTZ91_RS04115 Protein ID WP_000052076.1
Coordinates 871652..871840 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HTZ91_RS04120 Protein ID WP_001059690.1
Coordinates 871869..872129 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HTZ91_RS04085 867605..868162 + 558 WP_000824491.1 hypothetical protein -
HTZ91_RS04090 868503..869189 + 687 WP_001574556.1 thermonuclease family protein -
HTZ91_RS04095 869546..869746 + 201 WP_001059082.1 cold-shock protein -
HTZ91_RS04100 870243..870461 - 219 WP_000005879.1 hypothetical protein -
HTZ91_RS04105 870523..870807 - 285 WP_001004401.1 hypothetical protein -
HTZ91_RS04110 870895..871464 - 570 WP_001106663.1 hypothetical protein -
HTZ91_RS04115 871652..871840 - 189 WP_000052076.1 hypothetical protein Toxin
HTZ91_RS04120 871869..872129 - 261 WP_001059690.1 hypothetical protein Antitoxin
HTZ91_RS04125 872470..872673 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HTZ91_RS04130 872670..872906 - 237 WP_000368687.1 hypothetical protein -
HTZ91_RS04135 873131..873712 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
HTZ91_RS04140 873785..874402 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
HTZ91_RS04145 874559..875053 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
HTZ91_RS04150 875452..875874 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
HTZ91_RS04155 876022..876738 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T168368 WP_000052076.1 NZ_CP059155:c871840-871652 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T168368 NZ_CP075737:c1161377-1161123 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATTTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT168368 WP_001059690.1 NZ_CP059155:c872129-871869 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT168368 NZ_CP075737:c1161625-1161374 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References