Detailed information of TA system TA168367

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 384072..384604
• Replicon: chromosome
• Accession: NZ_CP059155
• Organism: Staphylococcus aureus strain WKZ-2

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: HTZ91_RS01695
• Protein ID: WP_123090134.1
• Coordinates: 384284..384604 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IA75
• Locus tag: HTZ91_RS01690
• Protein ID: WP_001058492.1
• Coordinates: 384072..384281 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HTZ91_RS01650	379176..379679	+	504	WP_000934799.1	single-stranded DNA-binding protein	-
HTZ91_RS01655	379731..379973	+	243	WP_000897044.1	30S ribosomal protein S18	-
HTZ91_RS01660	380205..381038	-	834	WP_180372434.1	type II toxin-antitoxin system PemK/MazF family toxin	-
HTZ91_RS01665	381039..382253	-	1215	WP_123090135.1	site-specific integrase	-
HTZ91_RS01670	382552..383286	-	735	WP_000142630.1	helix-turn-helix domain-containing protein	-
HTZ91_RS01675	383436..383648	+	213	WP_053040300.1	helix-turn-helix transcriptional regulator	-
HTZ91_RS01680	383649..383921	+	273	WP_053040301.1	helix-turn-helix domain-containing protein	-
HTZ91_RS01685	383933..384079	+	147	WP_000784885.1	hypothetical protein	-
HTZ91_RS01690	384072..384281	+	210	WP_001058492.1	hypothetical protein	Antitoxin
HTZ91_RS01695	384284..384604	+	321	WP_123090134.1	DUF1474 family protein	Toxin
HTZ91_RS01700	384668..385537	+	870	WP_053040303.1	primase alpha helix C-terminal domain-containing protein	-
HTZ91_RS01705	385554..387023	+	1470	WP_180821714.1	virulence-associated E family protein	-
HTZ91_RS01710	387302..387664	+	363	WP_001039165.1	hypothetical protein	-
HTZ91_RS01715	387666..387929	+	264	WP_001804819.1	hypothetical protein	-
HTZ91_RS01720	387931..388572	+	642	WP_160187057.1	pathogenicity island protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	375116..398696	23580

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12636.18 Da
• Isoelectric Point: 4.8637

>T168367 WP_123090134.1 NZ_CP059155:384284-384604 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEGRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T168367 NZ_CP075737:c977298-977195 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8238.28 Da
• Isoelectric Point: 4.3718

>AT168367 WP_001058492.1 NZ_CP059155:384072-384281 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT168367 NZ_CP075737:977157-977428 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Antitoxin

• AlphaFold DB: X5IA75