Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 1079552..1081241 | Replicon | chromosome |
| Accession | NZ_CP059130 | ||
| Organism | Escherichia coli strain Ec55 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A061KTE0 |
| Locus tag | H0X92_RS05140 | Protein ID | WP_000365807.1 |
| Coordinates | 1080321..1081241 (+) | Length | 307 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | H0X92_RS05135 | Protein ID | WP_001295795.1 |
| Coordinates | 1079552..1080334 (+) | Length | 261 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H0X92_RS05130 (1076170) | 1076170..1079268 | - | 3099 | WP_000673070.1 | type I restriction endonuclease | - |
| H0X92_RS05135 (1079552) | 1079552..1080334 | + | 783 | WP_001295795.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| H0X92_RS05140 (1080321) | 1080321..1081241 | + | 921 | WP_000365807.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| H0X92_RS26510 (1081406) | 1081406..1082182 | - | 777 | WP_000171155.1 | site-specific integrase | - |
| H0X92_RS26515 (1082390) | 1082390..1082725 | - | 336 | WP_000996167.1 | Arm DNA-binding domain-containing protein | - |
| H0X92_RS05150 (1082952) | 1082952..1083110 | - | 159 | Protein_1008 | integrase | - |
| H0X92_RS05155 (1083159) | 1083159..1083344 | + | 186 | WP_000146240.1 | hypothetical protein | - |
| H0X92_RS05160 (1083559) | 1083559..1084173 | + | 615 | WP_001019923.1 | YagU family protein | - |
| H0X92_RS05165 (1084244) | 1084244..1084410 | + | 167 | Protein_1011 | tail fiber assembly protein | - |
| H0X92_RS05170 (1084422) | 1084422..1084751 | - | 330 | WP_001295797.1 | YkgJ family cysteine cluster protein | - |
| H0X92_RS05175 (1085058) | 1085058..1085768 | - | 711 | WP_001295798.1 | fimbrial chaperone EcpE | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC | 1073302..1121458 | 48156 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 307 a.a. Molecular weight: 34570.89 Da Isoelectric Point: 7.3239
>T168336 WP_000365807.1 NZ_CP059130:1080321-1081241 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE
Download Length: 921 bp
>T168336 NZ_CP075724:36258-36536 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCATCCCCATTTTGTTCTGGTTTATGAAGTCGATAGCCAGTGGGGTAAAGTGTAT
ATCCTGCGCGTATTGCATACTGCACAGAAGTGGCCATAG
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCATCCCCATTTTGTTCTGGTTTATGAAGTCGATAGCCAGTGGGGTAAAGTGTAT
ATCCTGCGCGTATTGCATACTGCACAGAAGTGGCCATAG
Antitoxin
Download Length: 261 a.a. Molecular weight: 29099.24 Da Isoelectric Point: 8.5975
>AT168336 WP_001295795.1 NZ_CP059130:1079552-1080334 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA
Download Length: 783 bp
>AT168336 NZ_CP075724:35989-36258 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGTGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCCGCTGCATGGCGGGAT
GAAATGCGCAGGAAGGTTGCCGATAAATGA
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGTGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCCGCTGCATGGCGGGAT
GAAATGCGCAGGAAGGTTGCCGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|