Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3350505..3351130 Replicon chromosome
Accession NZ_CP059125
Organism Escherichia coli strain EC45

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H0X93_RS16160 Protein ID WP_000911330.1
Coordinates 3350505..3350903 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag H0X93_RS16165 Protein ID WP_000450524.1
Coordinates 3350903..3351130 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0X93_RS16140 (3346383) 3346383..3346583 + 201 WP_000383836.1 YpfN family protein -
H0X93_RS16145 (3346693) 3346693..3347391 - 699 WP_000679823.1 esterase -
H0X93_RS16150 (3347465) 3347465..3349480 - 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
H0X93_RS16155 (3349495) 3349495..3350358 - 864 WP_001267507.1 neutral zinc metallopeptidase -
H0X93_RS16160 (3350505) 3350505..3350903 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
H0X93_RS16165 (3350903) 3350903..3351130 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
H0X93_RS16170 (3351284) 3351284..3351997 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
H0X93_RS16175 (3352210) 3352210..3353244 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
H0X93_RS16180 (3353261) 3353261..3354139 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
H0X93_RS16185 (3354285) 3354285..3354857 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
H0X93_RS16190 (3354857) 3354857..3355327 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T168311 WP_000911330.1 NZ_CP059125:c3350903-3350505 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T168311 NZ_CP075717:c88724-88575 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGGTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT168311 WP_000450524.1 NZ_CP059125:c3351130-3350903 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT168311 NZ_CP075717:88768-88829 [Escherichia coli]
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References