Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 6870..7363 Replicon plasmid pEc42_3
Accession NZ_CP059122
Organism Escherichia coli strain Ec42

Toxin (Protein)


Gene name TsxA Uniprot ID U9Y9W8
Locus tag H0X94_RS25290 Protein ID WP_001230709.1
Coordinates 6870..7124 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID U9Y4R8
Locus tag H0X94_RS25295 Protein ID WP_000151456.1
Coordinates 7121..7363 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0X94_RS25915 2381..2533 + 153 Protein_1 FlmC family protein -
H0X94_RS25250 (H0X94_25130) 2481..2600 + 120 WP_227525580.1 Hok/Gef family protein -
H0X94_RS25255 (H0X94_25135) 2751..3347 + 597 WP_000125165.1 ProQ/FINO family protein -
H0X94_RS25260 (H0X94_25140) 3365..3649 - 285 WP_001542021.1 hypothetical protein -
H0X94_RS25265 (H0X94_25145) 3728..4393 - 666 WP_000532148.1 division plane positioning ATPase MipZ -
H0X94_RS25270 (H0X94_25150) 4618..4866 + 249 WP_001729107.1 hypothetical protein -
H0X94_RS25275 (H0X94_25155) 4982..5311 + 330 WP_001542022.1 hypothetical protein -
H0X94_RS25280 (H0X94_25160) 5712..6227 + 516 WP_001025393.1 J domain-containing protein -
H0X94_RS25285 (H0X94_25165) 6331..6873 + 543 WP_001083904.1 hypothetical protein -
H0X94_RS25290 (H0X94_25170) 6870..7124 + 255 WP_001230709.1 hypothetical protein Toxin
H0X94_RS25295 (H0X94_25175) 7121..7363 + 243 WP_000151456.1 hypothetical protein Antitoxin
H0X94_RS25300 (H0X94_25180) 7934..8227 + 294 WP_000673428.1 hypothetical protein -
H0X94_RS25920 8639..9082 - 444 WP_000192626.1 hypothetical protein -
H0X94_RS25310 (H0X94_25190) 9379..9561 + 183 WP_000833470.1 type II toxin-antitoxin system HicA family toxin -
H0X94_RS25315 (H0X94_25195) 9586..10023 + 438 WP_000466318.1 type II toxin-antitoxin system HicB family antitoxin -
H0X94_RS25320 (H0X94_25200) 10154..10474 - 321 WP_001310435.1 hypothetical protein -
H0X94_RS25325 (H0X94_25205) 10808..10986 - 179 Protein_17 hypothetical protein -
H0X94_RS25330 (H0X94_25210) 11023..11286 - 264 WP_000224227.1 hypothetical protein -
H0X94_RS25335 (H0X94_25215) 11288..11737 - 450 WP_219334570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..58815 58815


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9942.47 Da        Isoelectric Point: 10.1206

>T168297 WP_001230709.1 NZ_CP059122:6870-7124 [Escherichia coli]
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA

Download         Length: 255 bp

>T168297 NZ_CP075716:975263-975370 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9136.45 Da        Isoelectric Point: 7.2775

>AT168297 WP_000151456.1 NZ_CP059122:7121-7363 [Escherichia coli]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP

Download         Length: 243 bp

>AT168297 NZ_CP075716:c975213-975150 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G9H8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A3G9GNF5

References