Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4368404..4368999 Replicon chromosome
Accession NZ_CP059119
Organism Escherichia coli strain Ec42

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag H0X94_RS21050 Protein ID WP_000239581.1
Coordinates 4368404..4368754 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag H0X94_RS21055 Protein ID WP_001223213.1
Coordinates 4368748..4368999 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0X94_RS21030 (4363858) 4363858..4364880 - 1023 WP_001361374.1 ABC transporter permease -
H0X94_RS21035 (4364894) 4364894..4366396 - 1503 WP_001522399.1 sugar ABC transporter ATP-binding protein -
H0X94_RS21040 (4366529) 4366529..4367485 - 957 WP_001522398.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
H0X94_RS21045 (4367795) 4367795..4368325 + 531 WP_000055075.1 inorganic diphosphatase -
H0X94_RS21050 (4368404) 4368404..4368754 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
H0X94_RS21055 (4368748) 4368748..4368999 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
H0X94_RS21060 (4369211) 4369211..4369552 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
H0X94_RS21065 (4369555) 4369555..4373334 - 3780 WP_001522396.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T168282 WP_000239581.1 NZ_CP059119:c4368754-4368404 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T168282 NZ_CP075697:c4744757-4744650 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT168282 WP_001223213.1 NZ_CP059119:c4368999-4368748 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT168282 NZ_CP075697:4744810-4744871 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References