Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 2265964..2266594 Replicon chromosome
Accession NZ_CP059089
Organism Pantoea agglomerans strain AR1a

Toxin (Protein)


Gene name hicA Uniprot ID A0A379AGD8
Locus tag H0Z11_RS11645 Protein ID WP_010245321.1
Coordinates 2266412..2266594 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A349IF99
Locus tag H0Z11_RS11640 Protein ID WP_010245317.1
Coordinates 2265964..2266389 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0Z11_RS11625 (H0Z11_11615) 2261168..2262322 + 1155 WP_207874351.1 efflux RND transporter periplasmic adaptor subunit -
H0Z11_RS11630 (H0Z11_11620) 2262335..2265487 + 3153 WP_069026200.1 multidrug efflux RND transporter permease subunit OqxB -
H0Z11_RS11635 (H0Z11_11625) 2265575..2265928 - 354 WP_207874352.1 type II toxin-antitoxin system HicB family antitoxin -
H0Z11_RS11640 (H0Z11_11630) 2265964..2266389 - 426 WP_010245317.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H0Z11_RS11645 (H0Z11_11635) 2266412..2266594 - 183 WP_010245321.1 type II toxin-antitoxin system HicA family toxin Toxin
H0Z11_RS11650 (H0Z11_11640) 2266792..2267286 - 495 WP_010245324.1 Rrf2 family transcriptional regulator -
H0Z11_RS11655 (H0Z11_11645) 2267494..2268678 - 1185 WP_207874354.1 MFS transporter -
H0Z11_RS11660 (H0Z11_11650) 2268881..2269810 + 930 WP_207874356.1 DNA replication terminus site-binding protein -
H0Z11_RS11665 (H0Z11_11655) 2269854..2271251 - 1398 WP_207874358.1 class II fumarate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7000.12 Da        Isoelectric Point: 11.0643

>T168253 WP_010245321.1 NZ_CP059089:c2266594-2266412 [Pantoea agglomerans]
MKYSEFRRWLIQQGAILTKHRSGSSHFKVFLGDRQSIFPDHGAKEMPEGTRRKILKDLGL

Download         Length: 183 bp

>T168253 NZ_CP075668:c18974-18588 [Escherichia coli]
ATGAAATTCGTTAGTTCACAGGAAATGATTGAGTTTCATGACCGCTTGATTTCGCGTGATGGTGGCGTGGCGGGTATGCC
AGAACCCGGTCGCGCTGACGCGATCATTCATCGTGTTTTGAACATGTATCATTATGAAGGTGTGACAGATATTATGGATC
TGGCTGCCGTGTATTTAGTTGCTATTGCTCGTGGTCACATTTTCAACGATGCAAATAAGCGAACAGCCTTGTTTGTTGCA
CAGGTTTTTTTAAAACGGAATGGTATACATATTATTAGTTCGCGTATTTCGTTTGATGAAATGCAAATTATCGCTTTGAA
TGCTGCAACAGGAGAATATAACTGGAAGATGGTTTCTGACCATCTTAAAGCCATTATTTTAAATTAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15499.78 Da        Isoelectric Point: 4.8263

>AT168253 WP_010245317.1 NZ_CP059089:c2266389-2265964 [Pantoea agglomerans]
MFNYAVRLTHDAKTDTYEVSCRDLPLLHSVGDTVEEALAEAEDGLVTAISLEMDTRRPIPVASKPLEGEYIVSVPVLVAM
KAALYNAMIETGTRKVDLARQLGVNGPQVDRLLDVEHSSKVENVELALAQLGRKARIEIRT

Download         Length: 426 bp

>AT168253 NZ_CP075668:c19195-18971 [Escherichia coli]
ATGTTTACATGTAACTATAGCCATGCTCGCGATAACCTGGCCTCGTTGCTCGAGCTGGCGGTTGATGAAAATCAGCCTGT
TGAGATTCAGCGCCGTAAAGGTGGCGCGGCTGTACTGGTTGATAAAGACGCTTTTGAACGATACCGTAAAGCGGCTCTTG
ATGCTGAGTTTGCTGAGATCATGCAAAGTCATGGGACGGCCTATACGGAGCTTTCTAAGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379AGD8

Antitoxin

Source ID Structure
AlphaFold DB A0A349IF99

References