Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2153735..2155296 Replicon chromosome
Accession NZ_CP059089
Organism Pantoea agglomerans strain AR1a

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag H0Z11_RS11110 Protein ID WP_207874269.1
Coordinates 2153983..2155296 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag H0Z11_RS11105 Protein ID WP_022625644.1
Coordinates 2153735..2153983 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0Z11_RS11085 (H0Z11_11075) 2148982..2151207 + 2226 WP_031592293.1 iron ABC transporter permease -
H0Z11_RS11090 (H0Z11_11080) 2151204..2152265 + 1062 WP_207874263.1 ABC transporter ATP-binding protein -
H0Z11_RS11095 (H0Z11_11085) 2152289..2153083 + 795 WP_207874265.1 inositol monophosphatase family protein -
H0Z11_RS11100 (H0Z11_11090) 2153117..2153554 - 438 WP_207874267.1 GNAT family N-acetyltransferase -
H0Z11_RS11105 (H0Z11_11095) 2153735..2153983 + 249 WP_022625644.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
H0Z11_RS11110 (H0Z11_11100) 2153983..2155296 + 1314 WP_207874269.1 type II toxin-antitoxin system HipA family toxin Toxin
H0Z11_RS11115 (H0Z11_11105) 2155434..2155607 + 174 WP_230873490.1 type II toxin-antitoxin system MqsA family antitoxin -
H0Z11_RS11120 (H0Z11_11110) 2155934..2157355 + 1422 WP_207874271.1 M24 family metallopeptidase -
H0Z11_RS11125 (H0Z11_11115) 2157431..2159476 + 2046 WP_207874273.1 FUSC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-54)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49165.76 Da        Isoelectric Point: 8.4280

>T168252 WP_207874269.1 NZ_CP059089:2153983-2155296 [Pantoea agglomerans]
MQRLIAWMNGERVGVLTRQRNGAHEFQYDTAWLSNPLSRPLSLSMPLQVKAITSHAVINFFDNLLPDSPLIRDRIVARYQ
IKSRQPFDLLQEVGRDSVGATMLLPPDMPLPALQARYEVLDETRLESVLSAYQSDIPLGMLREETDFRISVAGAQEKTAL
LLTDEGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARALGIDVPQATIIRAGQMRALAVERFDRRW
SRDKTRLIRLPQEDFCQALGLPSSTKYESDGGPGIAEIMQILMGSSNAIEDRYRFMMFQVFQWLIGATDGHAKNFSLFIE
RGGSYRLTPFYDVMSGYPVLGGTGLNKRALKLAMGLRATKGKKTEIDKIFPRHFIATAKSVSFDRDSLQQIFDFFIKAFP
QAVVSVRDALPPDFPQHIADAIFSHSLIMLERLRHKE

Download         Length: 1314 bp

>T168252 NZ_CP075668:11756-12031 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
CGCCGCCAGAATGGTACAGTCCCTGATACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9363.61 Da        Isoelectric Point: 5.0775

>AT168252 WP_022625644.1 NZ_CP059089:2153735-2153983 [Pantoea agglomerans]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENAPDSTSLATLFKLLQSLELSLEVQEKEEASAPQLHDED
EW

Download         Length: 249 bp

>AT168252 NZ_CP075668:11472-11756 [Escherichia coli]
ATACAAATGAAAAACAATACCGCACAGGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCACTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGATATCCGGACAGATTATCGACCATCAGGCTGTACAGGCCTGG
GCAGACAGCCTCAGTACTGACAATCCGTTACCGGTTCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References