Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1581314..1581904 Replicon chromosome
Accession NZ_CP059089
Organism Pantoea agglomerans strain AR1a

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag H0Z11_RS08440 Protein ID WP_208002994.1
Coordinates 1581572..1581904 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag H0Z11_RS08435 Protein ID WP_208002993.1
Coordinates 1581314..1581571 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0Z11_RS08420 (H0Z11_08410) 1577262..1578284 + 1023 WP_208002992.1 LLM class flavin-dependent oxidoreductase -
H0Z11_RS08425 (H0Z11_08415) 1578400..1578582 + 183 Protein_1405 hypothetical protein -
H0Z11_RS08430 (H0Z11_08420) 1578770..1580989 + 2220 WP_241866648.1 catalase/peroxidase HPI -
H0Z11_RS08435 (H0Z11_08425) 1581314..1581571 + 258 WP_208002993.1 antitoxin Antitoxin
H0Z11_RS08440 (H0Z11_08430) 1581572..1581904 + 333 WP_208002994.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
H0Z11_RS08450 (H0Z11_08440) 1582384..1583505 + 1122 WP_208002995.1 Gfo/Idh/MocA family oxidoreductase -
H0Z11_RS08455 (H0Z11_08445) 1583606..1584436 - 831 WP_208002996.1 glycosyltransferase family 8 protein -
H0Z11_RS08460 (H0Z11_08450) 1584449..1585831 - 1383 WP_208002997.1 D-arabinono-1,4-lactone oxidase -
H0Z11_RS08465 (H0Z11_08455) 1585915..1586547 - 633 WP_208002998.1 TetR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(5-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11915.74 Da        Isoelectric Point: 7.8384

>T168251 WP_208002994.1 NZ_CP059089:1581572-1581904 [Pantoea agglomerans]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNAFTRLPIVVPVTSGGNFARAAGFTVSLDGAGCRTTGVIRCDQPRTL
DMEAREGRRLERLPEAIVNEVLARLEAILS

Download         Length: 333 bp

>T168251 NZ_CP075668:c2433-2284 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9323.84 Da        Isoelectric Point: 5.0348

>AT168251 WP_208002993.1 NZ_CP059089:1581314-1581571 [Pantoea agglomerans]
MFITRLKKVGGSVMLAVPPAVLKTLSLSTNSEVGMTIDNGCLIVKPQNRPRYSLEELLAQCDPHAEMSQEDREWIDAPAA
GKEIL

Download         Length: 258 bp

>AT168251 NZ_CP075668:2482-2538 [Escherichia coli]
GTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References