Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1545540..1547185 Replicon chromosome
Accession NZ_CP059089
Organism Pantoea agglomerans strain AR1a

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag H0Z11_RS08265 Protein ID WP_208002982.1
Coordinates 1545869..1547185 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag H0Z11_RS08260 Protein ID WP_227024310.1
Coordinates 1545540..1545776 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0Z11_RS08240 (H0Z11_08230) 1541369..1542778 + 1410 WP_010248093.1 NADP-dependent phosphogluconate dehydrogenase -
H0Z11_RS08245 (H0Z11_08235) 1542814..1544112 - 1299 WP_208002980.1 M14 family metallopeptidase -
H0Z11_RS08250 (H0Z11_08240) 1544219..1545010 - 792 WP_115758976.1 ABC transporter substrate-binding protein -
H0Z11_RS08255 (H0Z11_08245) 1545077..1545553 - 477 WP_022625009.1 YbaK/prolyl-tRNA synthetase associated domain-containing protein -
H0Z11_RS08260 (H0Z11_08250) 1545540..1545776 - 237 WP_227024310.1 helix-turn-helix domain-containing protein Antitoxin
H0Z11_RS08265 (H0Z11_08255) 1545869..1547185 - 1317 WP_208002982.1 HipA domain-containing protein Toxin
H0Z11_RS08270 (H0Z11_08260) 1547299..1547910 - 612 WP_031591333.1 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE -
H0Z11_RS08275 (H0Z11_08265) 1547904..1548680 - 777 WP_010670962.1 imidazole glycerol phosphate synthase subunit HisF -
H0Z11_RS08280 (H0Z11_08270) 1548662..1549399 - 738 WP_031591331.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
H0Z11_RS08285 (H0Z11_08275) 1549399..1549989 - 591 WP_008926061.1 imidazole glycerol phosphate synthase subunit HisH -
H0Z11_RS08290 (H0Z11_08280) 1549989..1551056 - 1068 WP_010670960.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
H0Z11_RS08295 (H0Z11_08285) 1551053..1552129 - 1077 WP_208002983.1 histidinol-phosphate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-354)

Antitoxin

Cro/C1-type helix-turn-helix domain

(2-52)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49701.53 Da        Isoelectric Point: 5.6571

>T168250 WP_208002982.1 NZ_CP059089:c1547185-1545869 [Pantoea agglomerans]
MLTIQLFIKGRWHDAAQLNIQKPSQGRESAALLAYDFDYAADYLDRNDYASCSLNYPVMLIGSYAAPPWFSFLDDIMPAG
ASRRYWVQQLGLQGKSAAEQDYWLLKSGTIAPVGNLRIKESVPALPAQSQLRDRRFPSEWVIERDSDFLAYAQQMGAASG
GATGAGGEAPKLLLRCTPQHEVWIDTWQDDADNQDTHYLVKYPRGTRSAIDCDILRAEYHYYHELEAMGFDTIPCGHMKL
REGSRYPSLWLPRFDVAYIDGQKVMYGLESVYSILQKPPGSYLNHFEVIRTLIKRLNPDRCAQEAFVIEWVKRDMLNIVF
GNSDNHGRNSAILKKNTGMWLAPIYDFAPMKADPEGVVRTTQWGSPFEEGGHYQWKLIADALSDLVPSDRLLAELASLTR
LLTGLKERLIQRGVPESILTMPAMGFDYLDQRIEGWQL

Download         Length: 1317 bp

>T168250 NZ_CP075667:30203-30619 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8827.20 Da        Isoelectric Point: 11.1414

>AT168250 WP_227024310.1 NZ_CP059089:c1545776-1545540 [Pantoea agglomerans]
MKLRKNVLGFSQERYAALAGISRRTLSDIEQDRENTTLSTLNRALKPLGLKTGIVPRQPHMLQTLMLQLTSGENRDHP

Download         Length: 237 bp

>AT168250 NZ_CP075667:29976-30206 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References