Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1431749..1432392 Replicon chromosome
Accession NZ_CP059089
Organism Pantoea agglomerans strain AR1a

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag H0Z11_RS07815 Protein ID WP_208002959.1
Coordinates 1431749..1432165 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag H0Z11_RS07820 Protein ID WP_109650817.1
Coordinates 1432162..1432392 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0Z11_RS07790 (H0Z11_07780) 1427653..1428228 - 576 WP_031593348.1 bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase -
H0Z11_RS07795 (H0Z11_07785) 1428741..1429448 - 708 WP_208002957.1 phosphatase PAP2 family protein -
H0Z11_RS07800 (H0Z11_07790) 1429494..1430462 - 969 WP_208002958.1 GTP-binding protein -
H0Z11_RS07805 (H0Z11_07795) 1430539..1431111 - 573 WP_003854146.1 elongation factor P-like protein YeiP -
H0Z11_RS07810 (H0Z11_07800) 1431455..1431709 + 255 WP_031292689.1 YkgJ family cysteine cluster protein -
H0Z11_RS07815 (H0Z11_07805) 1431749..1432165 - 417 WP_208002959.1 type II toxin-antitoxin system VapC family toxin Toxin
H0Z11_RS07820 (H0Z11_07810) 1432162..1432392 - 231 WP_109650817.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
H0Z11_RS07825 (H0Z11_07815) 1432861..1433991 + 1131 WP_208002960.1 fused PTS fructose transporter subunit IIA/HPr protein -
H0Z11_RS07830 (H0Z11_07820) 1433988..1434926 + 939 WP_010248301.1 1-phosphofructokinase -
H0Z11_RS07835 (H0Z11_07825) 1434943..1436655 + 1713 WP_208002961.1 PTS fructose transporter subunit IIBC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15220.48 Da        Isoelectric Point: 6.7137

>T168249 WP_208002959.1 NZ_CP059089:c1432165-1431749 [Pantoea agglomerans]
VNKTYMLDTNICSFIMREQPEEVIRRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHIQLVDAFCARLDAVLSWDRA
AADATTEIKAALAAAGTPMDPSDTAIAGHAIAARAILVTNNTREFERVPGLQLEEWVS

Download         Length: 417 bp

>T168249 NZ_CP075667:c25791-25486 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8890.04 Da        Isoelectric Point: 4.6182

>AT168249 WP_109650817.1 NZ_CP059089:c1432392-1432162 [Pantoea agglomerans]
MRIVSVFKNGNNRAIRLPRDMDFEGVSELEIIREGDAIILRPVRPTWRSFTQFEKADSDFMAQREDVVSDEGRFDL

Download         Length: 231 bp

>AT168249 NZ_CP075667:c26011-25793 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References