Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipB(antitoxin)
Location 2307369..2307994 Replicon chromosome
Accession NZ_CP059084
Organism Pantoea ananatis strain OC5a

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag H0Z12_RS23005 Protein ID WP_241866515.1
Coordinates 2307608..2307994 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag H0Z12_RS12060 Protein ID WP_013025828.1
Coordinates 2307369..2307608 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0Z12_RS12045 (H0Z12_12040) 2302961..2304349 + 1389 WP_014605798.1 MFS transporter -
H0Z12_RS12050 (H0Z12_12045) 2304372..2306747 + 2376 WP_207806271.1 glycoside hydrolase family 3 N-terminal domain-containing protein -
H0Z12_RS12055 (H0Z12_12050) 2306811..2307254 - 444 WP_015700266.1 GNAT family N-acetyltransferase -
H0Z12_RS12060 (H0Z12_12055) 2307369..2307608 + 240 WP_013025828.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
H0Z12_RS23005 2307608..2307994 + 387 WP_241866515.1 HipA N-terminal domain-containing protein Toxin
H0Z12_RS23010 2308022..2308717 + 696 WP_277884392.1 HipA domain-containing protein -
H0Z12_RS12070 (H0Z12_12065) 2308744..2309160 - 417 WP_014605803.1 GFA family protein -
H0Z12_RS12075 (H0Z12_12070) 2309611..2311479 - 1869 WP_013025825.1 low affinity potassium transporter Kup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(3-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-63)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14207.36 Da        Isoelectric Point: 7.5936

>T168242 WP_241866515.1 NZ_CP059084:2307608-2307994 [Pantoea ananatis]
MAKLIAWINGERTGTLTLHHNGALHFQYDANWLQHPLARPLSLSLPLQRAAMHSEKVVHFFENLLFPSALIEKDFYPTHP
IKSCEVFAALQKVGHTLPGALSLLPAKRQPVAPDQATHSVFSPADEAQ

Download         Length: 387 bp

>T168242 NZ_CP075665:4399737-4400087 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8746.94 Da        Isoelectric Point: 7.2012

>AT168242 WP_013025828.1 NZ_CP059084:2307369-2307608 [Pantoea ananatis]
MIYSPRQLANQVRLLRQQNGWTQVELAKKVGLKQATLSHFENAPDTTSLATLFKILQALDLALSLHENSASSAPAEDAW

Download         Length: 240 bp

>AT168242 NZ_CP075665:4399492-4399743 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References