Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 1991166..1991901 Replicon chromosome
Accession NZ_CP059084
Organism Pantoea ananatis strain OC5a

Toxin (Protein)


Gene name relE Uniprot ID A0A8A4K8B1
Locus tag H0Z12_RS10560 Protein ID WP_014605594.1
Coordinates 1991166..1991558 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H0Z12_RS10565 Protein ID WP_014605595.1
Coordinates 1991548..1991901 (+) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0Z12_RS10545 (H0Z12_10540) 1986462..1987634 - 1173 WP_013026120.1 FMNH2-dependent alkanesulfonate monooxygenase -
H0Z12_RS10550 (H0Z12_10545) 1987913..1989799 + 1887 WP_028715241.1 aliphatic sulfonate ABC transporter substrate-binding protein -
H0Z12_RS10555 (H0Z12_10550) 1989894..1990841 + 948 WP_105082159.1 sulfonate ABC transporter substrate-binding protein -
H0Z12_RS10560 (H0Z12_10555) 1991166..1991558 + 393 WP_014605594.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H0Z12_RS10565 (H0Z12_10560) 1991548..1991901 + 354 WP_014605595.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
H0Z12_RS10590 (H0Z12_10585) 1993444..1993983 - 540 WP_024472094.1 peptide-methionine (S)-S-oxide reductase MsrA -
H0Z12_RS10595 (H0Z12_10590) 1994346..1995413 - 1068 WP_105082158.1 two-component system sensor histidine kinase PmrB -
H0Z12_RS10600 (H0Z12_10595) 1995410..1996096 - 687 WP_029568859.1 two-component system response regulator PmrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(6-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(56-99)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14987.27 Da        Isoelectric Point: 10.1741

>T168233 WP_014605594.1 NZ_CP059084:1991166-1991558 [Pantoea ananatis]
MGFTLYVHKRFDRVFKKTRLTDSVLCYAAGDVFTGVFEADLGGGVIKKRLALHQGKRGGARTVIFFRQGTNLVYYDGWVK
NLSRKYAREIDEDQLDTYRDVARMFFRANSEVMSLLVRSGMVREVKCNEN

Download         Length: 393 bp

>T168233 NZ_CP075665:2259202-2259420 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13096.14 Da        Isoelectric Point: 7.2076

>AT168233 WP_014605595.1 NZ_CP059084:1991548-1991901 [Pantoea ananatis]
MKTEPAELSELLEDAKAFHALGLATDEEVESIAKRAKNRELRARIASVKPMTATEIKDVRMRWGMSQSLVALSFGMTVDS
VSKWERGEITPSPPVMRMLQLLRDNGPELFTSKHQGI

Download         Length: 354 bp

>AT168233 NZ_CP075665:2258802-2259176 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References