Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1896327..1896917 Replicon chromosome
Accession NZ_CP059084
Organism Pantoea ananatis strain OC5a

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag H0Z12_RS10115 Protein ID WP_207806652.1
Coordinates 1896585..1896917 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag H0Z12_RS10110 Protein ID WP_110286587.1
Coordinates 1896327..1896584 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0Z12_RS10090 (H0Z12_10085) 1891615..1892040 + 426 WP_207806649.1 pentapeptide repeat-containing protein -
H0Z12_RS10095 (H0Z12_10090) 1892328..1893566 - 1239 WP_207806650.1 MFS transporter -
H0Z12_RS10100 (H0Z12_10095) 1894313..1895275 + 963 WP_207806651.1 ferrochelatase -
H0Z12_RS22995 1895526..1895777 + 252 Protein_1707 hypothetical protein -
H0Z12_RS10105 (H0Z12_10100) 1895774..1895979 + 206 Protein_1708 helix-turn-helix transcriptional regulator -
H0Z12_RS10110 (H0Z12_10105) 1896327..1896584 + 258 WP_110286587.1 antitoxin Antitoxin
H0Z12_RS10115 (H0Z12_10110) 1896585..1896917 + 333 WP_207806652.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
H0Z12_RS10125 (H0Z12_10120) 1897178..1897945 - 768 WP_227022858.1 DgsA anti-repressor MtfA -
H0Z12_RS10130 (H0Z12_10125) 1898117..1898794 - 678 WP_013026204.1 hypothetical protein -
H0Z12_RS10135 (H0Z12_10130) 1899406..1900110 + 705 WP_022623305.1 phosphohydrolase -
H0Z12_RS10140 (H0Z12_10135) 1900184..1900438 + 255 WP_207806653.1 Arc family DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-83)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11930.69 Da        Isoelectric Point: 6.9802

>T168232 WP_207806652.1 NZ_CP059084:1896585-1896917 [Pantoea ananatis]
MDRGEIWLVSLDPIAGHEQSGRRPVLIVSPASFNQFTRLPVVVPVTNGGNFARAAGFTVSLDGAGTKTTGVIRCDQPRTI
DMEARNGKYLERIPEVIVNEVVARLEAILS

Download         Length: 333 bp

>T168232 NZ_CP075665:c1643110-1642862 [Escherichia coli]
ATGGGGAAAGCAGATAAGCTACTGGAAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAGCTGGTCGTTTTGTT
TTCCTCTCTGGGATATGTCAAAAAGGAAATGCAGGGCTCAAGAGTGCGGTTTTTCAATGCTGAAATCAACCACACCATAT
TAATGCATCGCCCACATCCAGAAAGTTATATTAAAGGTGGAACGCTGAAAGCGATTAAACAGAATCTGAAAGAGGCTGGG
GTATTATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9283.82 Da        Isoelectric Point: 4.5821

>AT168232 WP_110286587.1 NZ_CP059084:1896327-1896584 [Pantoea ananatis]
MYTTRLKKVGGSVMLAVPPAVLKTLGLSMDSEVGMTIDSGCLIIEPQKRPRYSLEELLAQCDPHAEISEEGREWIDAPAV
GKELL

Download         Length: 258 bp

>AT168232 NZ_CP075665:c1642865-1642521 [Escherichia coli]
ATGAAGCATCTAAAATATAAAGGATATTTAGGTACAGTAGAACCAGATTTTGAAAATAATATCCTGTACGGAAAACTGGC
GTTTATTCGAGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAGACATCGGTTGAGCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAGCCTGATACCCCGTTTAAAGGTGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGATTTATCACTGAACGCCTTTGTTAATAAGGCGCTGGAAAAAGA
AGTCAACCATCACACAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References