Detailed information of TA system TA168230

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1157115..1157793
• Replicon: chromosome
• Accession: NZ_CP059084
• Organism: Pantoea ananatis strain OC5a

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: H0Z12_RS06850
• Protein ID: WP_198801854.1
• Coordinates: 1157115..1157438 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: H0Z12_RS06855
• Protein ID: WP_207806553.1
• Coordinates: 1157488..1157793 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0Z12_RS06835 (H0Z12_06830)	1152568..1153986	+	1419	WP_105080401.1	DASS family sodium-coupled anion symporter	-
H0Z12_RS06840 (H0Z12_06835)	1154011..1155042	+	1032	WP_145032793.1	hydroxyacid dehydrogenase	-
H0Z12_RS06845 (H0Z12_06840)	1155370..1156317	+	948	WP_207806552.1	LysR family transcriptional regulator	-
H0Z12_RS06850 (H0Z12_06845)	1157115..1157438	-	324	WP_198801854.1	TA system toxin CbtA family protein	Toxin
H0Z12_RS06855 (H0Z12_06850)	1157488..1157793	-	306	WP_207806553.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
H0Z12_RS06860 (H0Z12_06855)	1157815..1158036	-	222	WP_032642916.1	DUF987 domain-containing protein	-
H0Z12_RS06865 (H0Z12_06860)	1158045..1158515	-	471	WP_207806554.1	DNA repair protein RadC	-
H0Z12_RS06870 (H0Z12_06865)	1158548..1159369	-	822	WP_207806679.1	DUF932 domain-containing protein	-
H0Z12_RS06875 (H0Z12_06870)	1159758..1160837	+	1080	WP_207806555.1	hypothetical protein	-
H0Z12_RS06880 (H0Z12_06875)	1161093..1161932	-	840	WP_007949333.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1151843..1182468	30625

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (12-106)

Antitoxin

• Antitoxin CbeA (4-101)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12152.95 Da
• Isoelectric Point: 6.3241

>T168230 WP_198801854.1 NZ_CP059084:c1157438-1157115 [Pantoea ananatis]
MHISSVPATVPVSSRLSPVMVWQQLLTYLLEHHYGLTLNDTPFHDDTAIEEHIDAGITLADAVNFLVEKYELARIDRKGF
TWREQPPFITATDILRAKKNIGLLPRS

Nucleotide

• Length: 324 bp

>T168230 NZ_CP075665:1407707-1407814 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11355.02 Da
• Isoelectric Point: 5.9483

>AT168230 WP_207806553.1 NZ_CP059084:c1157793-1157488 [Pantoea ananatis]
MQNSWGLKRDISPCFGARLVQEGCRLHFLADRAGISGTFNEEEALCLDQAFPLVMKQLELMLTTGELNPRHQHCVTLYHN
GLTCEADTLGSHGYVYIVIYP

Nucleotide

• Length: 306 bp

>AT168230 NZ_CP075665:c1407654-1407593 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT