Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5247092..5247759 Replicon chromosome
Accession NZ_CP059082
Organism Halomonas titanicae strain SOB56

Toxin (Protein)


Gene name vapC Uniprot ID A0A6N0Z796
Locus tag HZS52_RS24080 Protein ID WP_022519783.1
Coordinates 5247092..5247508 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A558JBE0
Locus tag HZS52_RS24085 Protein ID WP_022519784.1
Coordinates 5247505..5247759 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS52_RS24065 5243669..5244949 - 1281 WP_190373905.1 TRAP transporter large permease -
HZS52_RS24070 5244954..5245457 - 504 WP_190373906.1 TRAP transporter small permease -
HZS52_RS24075 5245542..5246552 - 1011 WP_035576900.1 TRAP transporter substrate-binding protein -
HZS52_RS24080 5247092..5247508 - 417 WP_022519783.1 type II toxin-antitoxin system VapC family toxin Toxin
HZS52_RS24085 5247505..5247759 - 255 WP_022519784.1 Arc family DNA-binding protein Antitoxin
HZS52_RS24090 5247870..5248175 + 306 WP_022519785.1 hypothetical protein -
HZS52_RS24095 5248559..5248867 + 309 WP_190373907.1 hypothetical protein -
HZS52_RS24100 5249220..5250170 - 951 WP_022519887.1 DUF808 domain-containing protein -
HZS52_RS24105 5250266..5250759 - 494 Protein_4738 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
HZS52_RS24110 5250749..5251110 - 362 Protein_4739 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
HZS52_RS24115 5251412..5251786 + 375 WP_039858811.1 GFA family protein -
HZS52_RS24120 5251827..5252009 - 183 WP_039858808.1 hypothetical protein -
HZS52_RS24125 5252044..5252568 - 525 WP_190373908.1 DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14831.96 Da        Isoelectric Point: 4.3331

>T168228 WP_022519783.1 NZ_CP059082:c5247508-5247092 [Halomonas titanicae]
MIVLDTNVVSEAMKPEPDPAVRAWLNEQSAETLYLSSVTLAELLFGIAALPNGKRKDMLSETLGGLVELFRGRILSFDVD
AARKYAELAVTARTAGRGFPVPDGYIAAIAVSQGYQVASRDMAPFEAANVDVINPFEA

Download         Length: 417 bp

>T168228 NZ_CP075665:c1132857-1132681 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9487.92 Da        Isoelectric Point: 7.2067

>AT168228 WP_022519784.1 NZ_CP059082:c5247759-5247505 [Halomonas titanicae]
MGMMTIRSIPDEVHNALKARAKQNHRSAEAEVRAILEEITRPESRLKMGDALADLGRKIGLTNEDVAVFEKVRDKTPAEP
MRFE

Download         Length: 255 bp

>AT168228 NZ_CP075665:c1132635-1132219 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N0Z796

Antitoxin

Source ID Structure
AlphaFold DB A0A558JBE0

References