Detailed information of TA system TA168226

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 4912093..4912595
• Replicon: chromosome
• Accession: NZ_CP059082
• Organism: Halomonas titanicae strain SOB56

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: HZS52_RS22710
• Protein ID: WP_190373756.1
• Coordinates: 4912341..4912595 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A653MNW0
• Locus tag: HZS52_RS22705
• Protein ID: WP_022520613.1
• Coordinates: 4912093..4912344 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZS52_RS22680	4907961..4908266	+	306	WP_190373752.1	hypothetical protein	-
HZS52_RS22685	4908623..4909525	-	903	WP_190373753.1	LysR family transcriptional regulator	-
HZS52_RS22690	4909615..4910634	+	1020	WP_190373754.1	NADP-dependent oxidoreductase	-
HZS52_RS22695	4910601..4911536	-	936	WP_190373755.1	LysR family transcriptional regulator	-
HZS52_RS22700	4911697..4911936	+	240	WP_053856851.1	hypothetical protein	-
HZS52_RS22705	4912093..4912344	+	252	WP_022520613.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HZS52_RS22710	4912341..4912595	+	255	WP_190373756.1	Txe/YoeB family addiction module toxin	Toxin
HZS52_RS22715	4912851..4913306	-	456	WP_190373757.1	GNAT family N-acetyltransferase	-
HZS52_RS22720	4913396..4913980	-	585	WP_027959861.1	HD domain-containing protein	-
HZS52_RS22725	4914100..4914462	-	363	WP_027959862.1	DUF1304 domain-containing protein	-
HZS52_RS22730	4914526..4915008	-	483	WP_190374963.1	GNAT family N-acetyltransferase	-
HZS52_RS22735	4915353..4915541	-	189	WP_022520619.1	tautomerase family protein	-
HZS52_RS22740	4915914..4917101	-	1188	WP_190373758.1	pyridoxal phosphate-dependent aminotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10226.84 Da
• Isoelectric Point: 9.9936

>T168226 WP_190373756.1 NZ_CP059082:4912341-4912595 [Halomonas titanicae]
MKLIFSESAWEDYLYWQKTDKKILNRINKLIKETKREPFEGVGKPEPLKHSLAGYWSRRINEEHRMVYKVTNDALLIAQL
RYHY

Nucleotide

• Length: 255 bp

>T168226 NZ_CP075665:646948-647051 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9285.56 Da
• Isoelectric Point: 4.4750

>AT168226 WP_022520613.1 NZ_CP059082:4912093-4912344 [Halomonas titanicae]
MDAISYTAARTNLAKTMEQVCEDHSPMIITRSKAQSVVMISLEDYEALQETAYLLRAPKNARRLLESVAELEQGGGQEKE
LLE

Nucleotide

• Length: 252 bp

>AT168226 NZ_CP075665:c647089-646818 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Antitoxin

• AlphaFold DB: A0A653MNW0