Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 2796446..2797392 Replicon chromosome
Accession NZ_CP059082
Organism Halomonas titanicae strain SOB56

Toxin (Protein)


Gene name slvT Uniprot ID L9U964
Locus tag HZS52_RS12880 Protein ID WP_009287632.1
Coordinates 2796874..2797392 (+) Length 173 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A6N0YYX8
Locus tag HZS52_RS12875 Protein ID WP_022522688.1
Coordinates 2796446..2796877 (+) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS52_RS12865 2791699..2792634 + 936 WP_138801637.1 Rpn family recombination-promoting nuclease/putative transposase -
HZS52_RS12870 2792643..2796269 - 3627 WP_190372918.1 exodeoxyribonuclease V subunit gamma -
HZS52_RS12875 2796446..2796877 + 432 WP_022522688.1 DUF2384 domain-containing protein Antitoxin
HZS52_RS12880 2796874..2797392 + 519 WP_009287632.1 RES domain-containing protein Toxin
HZS52_RS12885 2797487..2797801 - 315 WP_022522689.1 putative addiction module antidote protein -
HZS52_RS12890 2797806..2798102 - 297 WP_022522690.1 type II toxin-antitoxin system RelE/ParE family toxin -
HZS52_RS12895 2798275..2799957 + 1683 WP_009287633.1 dihydroxy-acid dehydratase -
HZS52_RS12900 2800070..2801263 + 1194 WP_190372919.1 chromate efflux transporter -
HZS52_RS12905 2801390..2801662 - 273 WP_008958942.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2690300..2820333 130033


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(11-163)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19535.15 Da        Isoelectric Point: 5.2387

>T168223 WP_009287632.1 NZ_CP059082:2796874-2797392 [Halomonas titanicae]
MIVLPELKTQAYRVHVPRWAFSPTSGAGAREHGGRLNRVGVDALYLSLEEQTALAEYKQLSALMPPGLIVSYTVSVTTIV
DFRSGYNSKWDSLWQELNCDWRKYWFNQRIEPPSWILGDMALEQGAKGILFPSLARDSGTNLVLYTETLTENDMLEVYDP
KGDLPHNARSWQ

Download         Length: 519 bp

>T168223 NZ_CP075664:51699-52097 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACTCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGACGTTCTGGATTACGACGCTGCTGCTGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGTTGA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15910.98 Da        Isoelectric Point: 6.4879

>AT168223 WP_022522688.1 NZ_CP059082:2796446-2796877 [Halomonas titanicae]
MAIDTVKESLNESSGYLVPDSFERFLADLKGAARKDRHPLINPKLFASALSIDIQTLANQAHVHRTTISRAQGAEKLQRY
LRDALRVLGAAADINGDFHDALFWFRNEPLSAFDYKTPEQLVSEGRAEDLLRYVQALQAGVVG

Download         Length: 432 bp

>AT168223 NZ_CP075664:51472-51699 [Escherichia coli]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCTGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCCGAATCATTACGCCTGCCGGAGAGACATGGGACGAATGGTTCGACGGAA
ACAGTGTCAGCGCTGATTTTATGGATAACAGGGAACAGCCTGGTATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L9U964

Antitoxin

Source ID Structure
AlphaFold DB A0A6N0YYX8

References