Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 1816232..1816742 Replicon chromosome
Accession NZ_CP059082
Organism Halomonas titanicae strain SOB56

Toxin (Protein)


Gene name relB Uniprot ID A0A653XY69
Locus tag HZS52_RS08470 Protein ID WP_022521756.1
Coordinates 1816232..1816495 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A653XX99
Locus tag HZS52_RS08475 Protein ID WP_022521757.1
Coordinates 1816488..1816742 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS52_RS08440 1811821..1812225 - 405 WP_022521750.1 VOC family protein -
HZS52_RS08445 1812248..1812850 - 603 WP_022521751.1 DNA-3-methyladenine glycosylase I -
HZS52_RS08450 1812865..1813530 - 666 WP_022521752.1 CDP-alcohol phosphatidyltransferase family protein -
HZS52_RS08455 1813747..1815222 - 1476 WP_190374551.1 PLP-dependent aminotransferase family protein -
HZS52_RS08460 1815315..1815764 + 450 WP_190374552.1 GNAT family N-acetyltransferase -
HZS52_RS08465 1815775..1816230 + 456 WP_190374553.1 rhodanese -
HZS52_RS08470 1816232..1816495 - 264 WP_022521756.1 Txe/YoeB family addiction module toxin Toxin
HZS52_RS08475 1816488..1816742 - 255 WP_022521757.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HZS52_RS08480 1816837..1817313 - 477 WP_190374554.1 YbaK/EbsC family protein -
HZS52_RS08485 1817391..1818644 - 1254 WP_190374555.1 cytosine deaminase -
HZS52_RS08490 1818661..1819926 - 1266 WP_190374556.1 cytosine permease -
HZS52_RS08495 1820202..1821650 + 1449 WP_009285894.1 diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10422.85 Da        Isoelectric Point: 8.4783

>T168222 WP_022521756.1 NZ_CP059082:c1816495-1816232 [Halomonas titanicae]
MSNRLLCWTNEAWSDYLYWQGQDKKTLKRINKLILDTQRSPFEGIGKPEPLRENLSGFWSRRIDDSHRLIYAVDESTLTI
IACRYHY

Download         Length: 264 bp

>T168222 NZ_CP075664:c41446-41297 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGGTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9437.63 Da        Isoelectric Point: 4.5388

>AT168222 WP_022521757.1 NZ_CP059082:c1816742-1816488 [Halomonas titanicae]
MRVISFTEARNGLKGVLDGVVNDADTTIITRRDAEDAVVMSLDYYNSLMETVYLMRSPANAEHLNKSIAQYRAGQAQPRE
LMDE

Download         Length: 255 bp

>AT168222 NZ_CP075664:41490-41551 [Escherichia coli]
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A653XY69

Antitoxin

Source ID Structure
AlphaFold DB A0A653XX99

References