Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 622599..623239 Replicon chromosome
Accession NZ_CP059082
Organism Halomonas titanicae strain SOB56

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HZS52_RS02975 Protein ID WP_190374124.1
Coordinates 622599..622781 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HZS52_RS02980 Protein ID WP_190374125.1
Coordinates 622820..623239 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS52_RS02945 618413..619600 - 1188 WP_190374123.1 Obg family GTPase CgtA -
HZS52_RS02950 619808..620065 - 258 WP_008957069.1 50S ribosomal protein L27 -
HZS52_RS02955 620095..620406 - 312 WP_022520761.1 50S ribosomal protein L21 -
HZS52_RS02960 620741..621745 + 1005 WP_009287882.1 octaprenyl diphosphate synthase -
HZS52_RS02970 622036..622269 + 234 WP_190374856.1 type II toxin-antitoxin system HicB family antitoxin -
HZS52_RS02975 622599..622781 + 183 WP_190374124.1 type II toxin-antitoxin system HicA family toxin Toxin
HZS52_RS02980 622820..623239 + 420 WP_190374125.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HZS52_RS02985 623535..623714 + 180 WP_176316341.1 transcriptional regulator -
HZS52_RS02990 623833..625017 + 1185 WP_081742685.1 MFS transporter -
HZS52_RS02995 625028..625810 - 783 WP_027958186.1 sulfite exporter TauE/SafE family protein -
HZS52_RS03000 625832..628129 - 2298 WP_190374126.1 ATP-dependent DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6712.92 Da        Isoelectric Point: 11.4653

>T168220 WP_190374124.1 NZ_CP059082:622599-622781 [Halomonas titanicae]
VDSRTLIKELKKDGWELVRVNGSHCHFRQPTKPGTVTVPHPKKNLKTGLVRAIRKSAGLL

Download         Length: 183 bp

>T168220 NZ_CP075663:4297126-4297461 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15166.12 Da        Isoelectric Point: 4.4306

>AT168220 WP_190374125.1 NZ_CP059082:622820-623239 [Halomonas titanicae]
MLFPIAIERGDEQHAYGVVVPDLNGCFSAGDTFEEALANVKAAIEGWLEVAVDYGDSIPEATSIEHHMDNPEYAGWIWAV
VDIDLTPYLGKSHKINVTLPDLLVKQIDDFVASHPGDKTRSGFLSRVAMAELARARKGA

Download         Length: 420 bp

>AT168220 NZ_CP075663:4296878-4297126 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References