Detailed information of TA system TA168219

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 137079..137751
• Replicon: chromosome
• Accession: NZ_CP059082
• Organism: Halomonas titanicae strain SOB56

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HZS52_RS00620
• Protein ID: WP_190373987.1
• Coordinates: 137079..137453 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HZS52_RS00625
• Protein ID: WP_022520049.1
• Coordinates: 137446..137751 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZS52_RS00610	132604..133239	-	636	WP_035576708.1	hypothetical protein	-
HZS52_RS00615	133236..136901	-	3666	WP_190373986.1	ATP-binding protein	-
HZS52_RS00620	137079..137453	+	375	WP_190373987.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HZS52_RS00625	137446..137751	+	306	WP_022520049.1	DNA-binding transcriptional regulator	Antitoxin
HZS52_RS00630	137755..138783	-	1029	WP_053856899.1	histone deacetylase family protein	-
HZS52_RS00635	138761..139486	-	726	WP_041157577.1	GntR family transcriptional regulator	-
HZS52_RS00640	139697..141253	+	1557	WP_190373988.1	ABC transporter substrate-binding protein	-
HZS52_RS00645	141331..142311	+	981	WP_138801577.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-120)

Antitoxin

• Cro/C1-type helix-turn-helix domain (45-89)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13377.54 Da
• Isoelectric Point: 10.3632

>T168219 WP_190373987.1 NZ_CP059082:137079-137453 [Halomonas titanicae]
MRVFKNKVFNKWAAKEGLNDAALLAAIDEIERGLIDADLGGHVLKKRVAISGRGKSGGVRTLLAYKVGNKAFFVYGFAKN
ARANISADELKALKHLAKELIGYSDKALANAIKHGVLIEVENDG

Nucleotide

• Length: 375 bp

>T168219 NZ_CP075663:4160842-4161249 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11218.02 Da
• Isoelectric Point: 8.9798

>AT168219 WP_022520049.1 NZ_CP059082:137446-137751 [Halomonas titanicae]
MDKSILDMVHETAQDLHAAGVMKETTLREFDALCLPPVKEYTAIQIKRIRTKNHASQGVFAAYLNTSVSTVQKWEQGQKK
PNGPSLKLLNLVAEKGLEILA

Nucleotide

• Length: 306 bp

>AT168219 NZ_CP075663:4160595-4160861 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA