Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 4487730..4488271 Replicon chromosome
Accession NZ_CP059068
Organism Rhodoferax sp. AJA081-3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HZ993_RS20985 Protein ID WP_209394641.1
Coordinates 4488005..4488271 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag HZ993_RS20980 Protein ID WP_209394640.1
Coordinates 4487730..4487984 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ993_RS20945 (HZ993_20900) 4482832..4483512 - 681 WP_209394633.1 HAD-IA family hydrolase -
HZ993_RS20950 (HZ993_20905) 4483667..4483891 + 225 WP_209394634.1 CopG family transcriptional regulator -
HZ993_RS20955 (HZ993_20910) 4483884..4484348 + 465 WP_209394635.1 PIN domain-containing protein -
HZ993_RS20960 (HZ993_20915) 4484374..4485507 + 1134 WP_209394636.1 histidinol-phosphate transaminase -
HZ993_RS20965 (HZ993_20920) 4485504..4486133 + 630 WP_209394637.1 imidazoleglycerol-phosphate dehydratase HisB -
HZ993_RS20970 (HZ993_20925) 4486199..4486858 + 660 WP_209394638.1 imidazole glycerol phosphate synthase subunit HisH -
HZ993_RS20975 (HZ993_20930) 4486920..4487660 + 741 WP_209394639.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
HZ993_RS20980 (HZ993_20935) 4487730..4487984 + 255 WP_209394640.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HZ993_RS20985 (HZ993_20940) 4488005..4488271 + 267 WP_209394641.1 Txe/YoeB family addiction module toxin Toxin
HZ993_RS20990 (HZ993_20945) 4488833..4489612 + 780 WP_209394642.1 imidazole glycerol phosphate synthase subunit HisF -
HZ993_RS20995 (HZ993_20950) 4489694..4490119 + 426 WP_209394643.1 phosphoribosyl-AMP cyclohydrolase -
HZ993_RS21000 (HZ993_20955) 4490170..4490547 + 378 WP_209394644.1 phosphoribosyl-ATP diphosphatase -
HZ993_RS21005 (HZ993_20960) 4490576..4490950 + 375 WP_209394645.1 histidine triad nucleotide-binding protein -
HZ993_RS21010 (HZ993_20965) 4491034..4491273 + 240 WP_209394646.1 Sec-independent protein translocase subunit TatA -
HZ993_RS21015 (HZ993_20970) 4491315..4491782 + 468 WP_209394647.1 Sec-independent protein translocase protein TatB -
HZ993_RS21020 (HZ993_20975) 4491782..4492576 + 795 WP_209394648.1 twin-arginine translocase subunit TatC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10096.50 Da        Isoelectric Point: 6.4558

>T168210 WP_209394641.1 NZ_CP059068:4488005-4488271 [Rhodoferax sp. AJA081-3]
MARAIRFTPVAWEDYLYWQGQDKKTLKRINTLVAAAVRDPFVGIGKPEPLMGNLAGYWSRRIDETHRLVYAVDDADLDVI
ACRGHYDD

Download         Length: 267 bp

>T168210 NZ_CP075663:c1197664-1197287 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCAGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCTC
CCGACTACTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATAACCCTGGGTAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9149.58 Da        Isoelectric Point: 10.0942

>AT168210 WP_209394640.1 NZ_CP059068:4487730-4487984 [Rhodoferax sp. AJA081-3]
MKVVTYSEARSALKTVLDRVHDDADVTVISRRDGADAVVMSLEHYQSIMETMHLLGTPANAAHLAKSIAQHKAGKAVRRK
LVPA

Download         Length: 255 bp

>AT168210 NZ_CP075663:c1198122-1197754 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAATAACGACCGCCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGACACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGGACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCTGATACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References