Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 3874145..3874875 Replicon chromosome
Accession NZ_CP059068
Organism Rhodoferax sp. AJA081-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HZ993_RS18210 Protein ID WP_209394139.1
Coordinates 3874465..3874875 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HZ993_RS18205 Protein ID WP_209394138.1
Coordinates 3874145..3874468 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ993_RS18185 (HZ993_18150) 3869670..3870581 + 912 WP_209394135.1 transcriptional regulator GcvA -
HZ993_RS18190 (HZ993_18155) 3870955..3871845 + 891 WP_209394136.1 acetylglutamate kinase -
HZ993_RS18195 (HZ993_18160) 3871905..3872630 + 726 WP_209394137.1 response regulator transcription factor -
HZ993_RS18200 (HZ993_18165) 3872651..3874105 + 1455 WP_209398583.1 sensor histidine kinase -
HZ993_RS18205 (HZ993_18170) 3874145..3874468 + 324 WP_209394138.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HZ993_RS18210 (HZ993_18175) 3874465..3874875 + 411 WP_209394139.1 type II toxin-antitoxin system VapC family toxin Toxin
HZ993_RS18215 (HZ993_18180) 3874952..3875656 + 705 WP_209394140.1 nucleoid occlusion factor SlmA -
HZ993_RS18220 (HZ993_18185) 3875869..3876486 + 618 WP_245213998.1 TetR/AcrR family transcriptional regulator -
HZ993_RS18225 (HZ993_18190) 3876524..3878320 + 1797 WP_209394141.1 acyl-CoA dehydrogenase C-terminal domain-containing protein -
HZ993_RS18230 (HZ993_18195) 3878376..3878810 + 435 WP_209394142.1 DUF2147 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-64)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14911.18 Da        Isoelectric Point: 7.2438

>T168209 WP_209394139.1 NZ_CP059068:3874465-3874875 [Rhodoferax sp. AJA081-3]
MILLDTVVLSELRKTKPNANVTNYLKAQAEGTTFLSALSIGEIEAGIERQRGHNPAFADELAQWLVALELQFSQYILPVT
PAIAKLWGRLCVQTGNKGIDNLIAATALCHNLSVVTRNTKHFEPTGVRVLNPFDAQ

Download         Length: 411 bp

>T168209 NZ_CP075663:1103151-1103438 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCAGAACGCTTATGGCAGCGATTAAGGGGGTGTGTGCTGCCGTTATCCGAACACCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCTCACCCTAACTATATAATTCTTTACCGTGTAGCCACTTTAAGCATTGAG
ATCGTGAGTGTAGTACACGCCAGACGCCAATTCCCCAAGCAGAACTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11971.64 Da        Isoelectric Point: 8.6793

>AT168209 WP_209394138.1 NZ_CP059068:3874145-3874468 [Rhodoferax sp. AJA081-3]
MQTPPTLSPANAWRLQDAKAQFSELVDNAMRGVPQHVTRRGKQAVVVLSEADFEALQRNAAAKQPRGLIEHLLAIPKTPV
PYQSKERTVADAEFPRLDLQPREIDFS

Download         Length: 324 bp

>AT168209 NZ_CP075663:1102959-1103147 [Escherichia coli]
ATGAATACGGCCCTTTCACCAATGGTTTCTGAGTTCGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAGCGAGCCTTGCAAATCCGCGCCCAGCAATTCCCCATGACGAGGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGTAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References