Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 2380054..2380868 | Replicon | chromosome |
| Accession | NZ_CP059068 | ||
| Organism | Rhodoferax sp. AJA081-3 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | - |
| Locus tag | HZ993_RS11095 | Protein ID | WP_209397914.1 |
| Coordinates | 2380054..2380554 (-) | Length | 167 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | - |
| Locus tag | HZ993_RS11100 | Protein ID | WP_209397916.1 |
| Coordinates | 2380551..2380868 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZ993_RS11080 (HZ993_11080) | 2375521..2377539 | + | 2019 | WP_209397908.1 | flagellar hook-associated protein FlgK | - |
| HZ993_RS11085 (HZ993_11085) | 2377565..2378833 | + | 1269 | WP_209397910.1 | flagellar hook-associated protein FlgL | - |
| HZ993_RS11090 (HZ993_11090) | 2378861..2380057 | + | 1197 | WP_209397912.1 | HDOD domain-containing protein | - |
| HZ993_RS11095 (HZ993_11095) | 2380054..2380554 | - | 501 | WP_209397914.1 | GNAT family N-acetyltransferase | Toxin |
| HZ993_RS11100 (HZ993_11100) | 2380551..2380868 | - | 318 | WP_209397916.1 | DUF1778 domain-containing protein | Antitoxin |
| HZ993_RS11105 (HZ993_11105) | 2380953..2382386 | - | 1434 | WP_209397918.1 | PLP-dependent aminotransferase family protein | - |
| HZ993_RS11110 (HZ993_11110) | 2382532..2383143 | + | 612 | WP_209397920.1 | LysE family translocator | - |
| HZ993_RS11115 (HZ993_11115) | 2383140..2384084 | + | 945 | WP_245213910.1 | DMT family transporter | - |
| HZ993_RS11120 (HZ993_11120) | 2384408..2385613 | + | 1206 | WP_209397922.1 | PLP-dependent aminotransferase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 167 a.a. Molecular weight: 18234.08 Da Isoelectric Point: 9.5438
>T168208 WP_209397914.1 NZ_CP059068:c2380554-2380054 [Rhodoferax sp. AJA081-3]
MTFGAPVPLQALHRLDSFDCGKPSLNEWLTRYARQSQASGSAKTFVVAHDDGVVGYFSLTVGQVDTLEAPERIRKGMGQY
PVPVVILARLAVAQQAQGHGVGIGMLQDAIRRTLLIAEQAGIRALLTHPLDADAARFYLRFGFEASPLRPDQLLLLLKDA
RRWVQV
MTFGAPVPLQALHRLDSFDCGKPSLNEWLTRYARQSQASGSAKTFVVAHDDGVVGYFSLTVGQVDTLEAPERIRKGMGQY
PVPVVILARLAVAQQAQGHGVGIGMLQDAIRRTLLIAEQAGIRALLTHPLDADAARFYLRFGFEASPLRPDQLLLLLKDA
RRWVQV
Download Length: 501 bp
>T168208 NZ_CP075663:977892-977999 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11457.99 Da Isoelectric Point: 7.2782
>AT168208 WP_209397916.1 NZ_CP059068:c2380868-2380551 [Rhodoferax sp. AJA081-3]
MTSAVAPHTPSARSANAARSARLGLRATDQQEAILRRAAEVAHKSLTDFILDSACLAAEQTLLDQRLFMVSGSQYQALMD
LLDRPAQDNPGLKDLFSHKAPWDKP
MTSAVAPHTPSARSANAARSARLGLRATDQQEAILRRAAEVAHKSLTDFILDSACLAAEQTLLDQRLFMVSGSQYQALMD
LLDRPAQDNPGLKDLFSHKAPWDKP
Download Length: 318 bp
>AT168208 NZ_CP075663:c977842-977779 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|