Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2245173..2245807 Replicon chromosome
Accession NZ_CP059068
Organism Rhodoferax sp. AJA081-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HZ993_RS10470 Protein ID WP_209397716.1
Coordinates 2245406..2245807 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HZ993_RS10465 Protein ID WP_209397714.1
Coordinates 2245173..2245406 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ993_RS10450 (HZ993_10450) 2242125..2243747 - 1623 WP_209397712.1 carboxyl transferase domain-containing protein -
HZ993_RS24390 2243868..2245115 + 1248 WP_245213905.1 AraC family transcriptional regulator -
HZ993_RS10465 (HZ993_10465) 2245173..2245406 + 234 WP_209397714.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HZ993_RS10470 (HZ993_10470) 2245406..2245807 + 402 WP_209397716.1 type II toxin-antitoxin system VapC family toxin Toxin
HZ993_RS10475 (HZ993_10475) 2245895..2247526 + 1632 WP_209397718.1 AMP-binding protein -
HZ993_RS10480 (HZ993_10480) 2247539..2248207 + 669 WP_209397720.1 glutathione S-transferase family protein -
HZ993_RS10485 (HZ993_10485) 2248290..2249996 - 1707 WP_209397722.1 acyl-CoA dehydrogenase family protein -
HZ993_RS10490 (HZ993_10490) 2250164..2250793 + 630 WP_209397724.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14689.03 Da        Isoelectric Point: 8.1080

>T168207 WP_209397716.1 NZ_CP059068:2245406-2245807 [Rhodoferax sp. AJA081-3]
MLKYLLDTNIVIYVIKRKPLNALQTFNLHAGHMAISSITLAELLHGAEKSTAPAQTLAVVEDFCSRLEILTYGPKAAQHY
GSIRASLEKIGKPIGVNDIHIAAHARSEGLTLVTNNLREFERVPALQFENWVA

Download         Length: 402 bp

>T168207 NZ_CP075663:977357-977464 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8805.92 Da        Isoelectric Point: 6.2751

>AT168207 WP_209397714.1 NZ_CP059068:2245173-2245406 [Rhodoferax sp. AJA081-3]
MSNSTVFTNNRSQAIRLPADMRLPASVKRVTVRARGMERIITPIENTWDSFFLDSPNVPEDFLPTRASQEQPDRESL

Download         Length: 234 bp

>AT168207 NZ_CP075663:c977304-977243 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References