Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1023393..1024101 Replicon chromosome
Accession NZ_CP059068
Organism Rhodoferax sp. AJA081-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HZ993_RS04775 Protein ID WP_209396123.1
Coordinates 1023393..1023821 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HZ993_RS04780 Protein ID WP_209396124.1
Coordinates 1023826..1024101 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ993_RS04750 (HZ993_04755) 1018674..1019072 - 399 WP_209396120.1 PIN domain-containing protein -
HZ993_RS04755 (HZ993_04760) 1019069..1019359 - 291 WP_245213818.1 type II toxin-antitoxin system VapB family antitoxin -
HZ993_RS04760 (HZ993_04765) 1019430..1020296 - 867 WP_209396121.1 GNAT family N-acetyltransferase -
HZ993_RS04765 (HZ993_04770) 1020302..1022473 - 2172 WP_209396122.1 methylmalonyl-CoA mutase -
HZ993_RS04770 (HZ993_04775) 1022637..1023308 + 672 WP_245213819.1 GntR family transcriptional regulator -
HZ993_RS04775 (HZ993_04780) 1023393..1023821 - 429 WP_209396123.1 VapC toxin family PIN domain ribonuclease Toxin
HZ993_RS04780 (HZ993_04785) 1023826..1024101 - 276 WP_209396124.1 hypothetical protein Antitoxin
HZ993_RS04785 (HZ993_04790) 1024247..1026409 + 2163 WP_209396125.1 sensor histidine kinase -
HZ993_RS04790 (HZ993_04795) 1026406..1027149 + 744 WP_209396126.1 response regulator -
HZ993_RS04795 (HZ993_04800) 1027222..1028142 - 921 WP_245213820.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15798.19 Da        Isoelectric Point: 7.3932

>T168205 WP_209396123.1 NZ_CP059068:c1023821-1023393 [Rhodoferax sp. AJA081-3]
MRALLDINVLIALHDGDHVHHQRAALWFESNIVHGWASCPLTQNGCLRIMSQPGYSSPQPLAVLVSMLHGSTTTAFHMLW
SDDISLLDAKYFHHTHMHSHGQLTDLYLLALAVKNGGRLVSFDQRIPLSAVHGARAEHLVKL

Download         Length: 429 bp

>T168205 NZ_CP075663:262152-262255 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9693.02 Da        Isoelectric Point: 6.4640

>AT168205 WP_209396124.1 NZ_CP059068:c1024101-1023826 [Rhodoferax sp. AJA081-3]
MRTTLDIADDVLYAAKEIAQREKKPLGTIISDLARRAFLNPEGITHAAGATGAAAPQVSERLASYGIHPLPTRGGIVSNE
LVDRLRDAEGI

Download         Length: 276 bp

>AT168205 NZ_CP075663:c262293-262022 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References