Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1018674..1019359 Replicon chromosome
Accession NZ_CP059068
Organism Rhodoferax sp. AJA081-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HZ993_RS04750 Protein ID WP_209396120.1
Coordinates 1018674..1019072 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HZ993_RS04755 Protein ID WP_245213818.1
Coordinates 1019069..1019359 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ993_RS04735 (HZ993_04740) 1013790..1015838 - 2049 WP_209396117.1 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -
HZ993_RS04740 (HZ993_04745) 1016069..1017601 - 1533 WP_209396118.1 acyl-CoA carboxylase subunit beta -
HZ993_RS04745 (HZ993_04750) 1017665..1018681 - 1017 WP_209396119.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
HZ993_RS04750 (HZ993_04755) 1018674..1019072 - 399 WP_209396120.1 PIN domain-containing protein Toxin
HZ993_RS04755 (HZ993_04760) 1019069..1019359 - 291 WP_245213818.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HZ993_RS04760 (HZ993_04765) 1019430..1020296 - 867 WP_209396121.1 GNAT family N-acetyltransferase -
HZ993_RS04765 (HZ993_04770) 1020302..1022473 - 2172 WP_209396122.1 methylmalonyl-CoA mutase -
HZ993_RS04770 (HZ993_04775) 1022637..1023308 + 672 WP_245213819.1 GntR family transcriptional regulator -
HZ993_RS04775 (HZ993_04780) 1023393..1023821 - 429 WP_209396123.1 VapC toxin family PIN domain ribonuclease -
HZ993_RS04780 (HZ993_04785) 1023826..1024101 - 276 WP_209396124.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(22-61)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14946.29 Da        Isoelectric Point: 7.8224

>T168204 WP_209396120.1 NZ_CP059068:c1019072-1018674 [Rhodoferax sp. AJA081-3]
MTYLLDTNICIYVINEQPAHVLQRLIQVGRESLVISTVTVAELAFGIEKSKRPGARAKLENFLSKFPIQDWGQDAAWVYG
RVRKSLEAKGQRIGERDLLLACQALALDATMVTNNTREFERVEGLKLENWVV

Download         Length: 399 bp

>T168204 NZ_CP075655:775-1053 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGAACCCGGGAACTGGTTATTCACCCCCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACCGCACAGAAGTGGCCATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10739.19 Da        Isoelectric Point: 6.3355

>AT168204 WP_245213818.1 NZ_CP059068:c1019359-1019069 [Rhodoferax sp. AJA081-3]
MTATTRTTTDSAMPAPSVAKVFTTGRSQAVRLPKAFRFNTAEVTIERQGDAIILRPKPDRETWAQQVLAAVAAFEPDFKL
ERSDEWPQPDREPLLP

Download         Length: 291 bp

>AT168204 NZ_CP075655:506-775 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGTCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGCCAGCAACTTGAGCGCGGTGATGTGCTTCCCCATGACATGGTCGAATCCTCAGCTACCGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References