Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3013661..3014289 Replicon chromosome
Accession NZ_CP059066
Organism Koleobacter methoxysyntrophicus strain NRmbB1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H0A61_RS14810 Protein ID WP_206707858.1
Coordinates 3013897..3014289 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H0A61_RS14805 Protein ID WP_206707857.1
Coordinates 3013661..3013891 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0A61_RS14775 3009705..3010283 - 579 WP_206707851.1 thymidine kinase -
H0A61_RS14780 3010351..3010533 - 183 WP_206707852.1 hypothetical protein -
H0A61_RS14785 3010536..3011261 - 726 WP_206707853.1 host-nuclease inhibitor Gam family protein -
H0A61_RS14790 3011350..3011580 - 231 WP_206707854.1 hypothetical protein -
H0A61_RS14795 3011681..3011947 - 267 WP_206707855.1 hypothetical protein -
H0A61_RS14800 3012072..3012992 - 921 WP_206707856.1 hypothetical protein -
H0A61_RS14805 3013661..3013891 + 231 WP_206707857.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H0A61_RS14810 3013897..3014289 + 393 WP_206707858.1 PIN domain-containing protein Toxin
H0A61_RS14815 3014436..3015302 + 867 WP_206707859.1 site-specific DNA-methyltransferase -
H0A61_RS14820 3015299..3017116 + 1818 WP_206707860.1 N-6 DNA methylase -
H0A61_RS14825 3017282..3018616 - 1335 WP_206707861.1 IS200/IS605 family accessory protein TnpB-related protein -
H0A61_RS14830 3018582..3019010 - 429 WP_206707862.1 IS200/IS605 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2935016..3019010 83994


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-113)

Antitoxin

SpoVT-AbrB domain

(9-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14521.11 Da        Isoelectric Point: 6.9045

>T168201 WP_206707858.1 NZ_CP059066:3013897-3014289 [Koleobacter methoxysyntrophicus]
MLDTNICIYIIKKKPVKVIERLKKLDIGDICISVITLAELCYGIEKSQNKERNRLALAAFLAPIEILPFSDEAAARYGEI
RAFLEKTGQIIGAYDLLIAAHAVSKNLILITNNVSEFGRVPCLSIENWTE

Download         Length: 393 bp

>T168201 NZ_CP075654:c18675-18289 [Escherichia coli]
ATGAAATTCGTTAGTTCACAGGAAGTGATTGAGTTTCATGACCGCTTGATTTCGCGTGATGGTGGCGTGGCGGGTATGCC
AGAACCCGGTCGCGCTGACGCGATCATTCATCGTGTTTTGAACATGTATCATTATGAAGGTGTGACAGATATTATGGATC
TGGCTGCCGTGTATTTAGTTGCTATTGCTCGTGGTCACATTTTCAACGATGCAAATAAGCGAACAGCCTTGTTTGTTGCA
CAGGTTTTTTTAAAACGGAATGGTGTACATATTATTAGTTCACGTATTTCGTTTGATGAAATGCAAATTATCGCTTTGAA
TGCTGCAACAGGAGAATATAACTGGAAGATGGTTTCTGACCATCTTAAAGCCATTATTCTAAATTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8970.16 Da        Isoelectric Point: 7.0125

>AT168201 WP_206707857.1 NZ_CP059066:3013661-3013891 [Koleobacter methoxysyntrophicus]
VDVAKIFENGRSQAVRLPKQYRFNDSEVFIKKVGDIVVLIPKESVWKSFEYGLKHFSEDFLNTRNQPEPEKRDDIQ

Download         Length: 231 bp

>AT168201 NZ_CP075654:c18896-18672 [Escherichia coli]
ATGTTTACATGTAACTATAGCCATGCTCGCGATAACCTGGCCTCGTTGCTCGAGCTGGCGGTTGATGAAAATCAGCCAGT
TGAGATTCAGCGCCGTAAAGGTGGCGCAGCTGTACTGGTTGATAAAGACGCTTTTGAACGATACCGTAAAGCGGCTCTTG
ATGCTGAGTTTGCTGAGATCATGCAAAGTCATGGGACGGCCTATACGGAGCTTTCTAAGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References