Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 191768..192395 Replicon chromosome
Accession NZ_CP059066
Organism Koleobacter methoxysyntrophicus strain NRmbB1

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag H0A61_RS00910 Protein ID WP_206708112.1
Coordinates 191768..192118 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag H0A61_RS00915 Protein ID WP_206708113.1
Coordinates 192120..192395 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0A61_RS00880 187848..188174 - 327 WP_206708106.1 YlbF family regulator -
H0A61_RS00885 188337..188882 - 546 WP_206708107.1 acetolactate synthase small subunit -
H0A61_RS00890 188958..189398 - 441 WP_206708108.1 VanZ family protein -
H0A61_RS00895 189903..190328 - 426 WP_206708109.1 hypothetical protein -
H0A61_RS00900 190288..190683 - 396 WP_206708110.1 hypothetical protein -
H0A61_RS00905 191022..191447 - 426 WP_206708111.1 MerR family transcriptional regulator -
H0A61_RS00910 191768..192118 - 351 WP_206708112.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
H0A61_RS00915 192120..192395 - 276 WP_206708113.1 ribbon-helix-helix protein, CopG family Antitoxin
H0A61_RS00920 192578..193765 - 1188 WP_206708114.1 alanine racemase -
H0A61_RS00925 193809..194429 - 621 WP_206708115.1 hypothetical protein -
H0A61_RS00930 194508..196061 - 1554 WP_206708116.1 NAD(P)H-hydrate dehydratase -
H0A61_RS00935 196058..196471 - 414 WP_206708117.1 holo-ACP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12889.14 Da        Isoelectric Point: 9.4357

>T168200 WP_206708112.1 NZ_CP059066:c192118-191768 [Koleobacter methoxysyntrophicus]
MIVKRGEVYYADLSPVVGSEQGGVRPVLIIQNDVGNKYSPTVIVAAITSQIDKAKLPTHVEIKAKGWGFDKDSVILLEQI
RTLDKKRLKEKITFLDHEIMAKVDKALKISLGLNEC

Download         Length: 351 bp

>T168200 NZ_CP075654:10992-11270 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACCGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGAATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10853.72 Da        Isoelectric Point: 6.4318

>AT168200 WP_206708113.1 NZ_CP059066:c192395-192120 [Koleobacter methoxysyntrophicus]
VAETKKIMITLPDSLLEEVDIIASMEKKNRSQFIREAMRLYIREREKRQIRENMKKGYMEMAKINLMLAEMALEAENDSL
KVYETRLAERE

Download         Length: 276 bp

>AT168200 NZ_CP075654:10723-10992 [Escherichia coli]
ATGACACAGGTTAACATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGGGCGCGGCGATGTGCTTTCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References