Detailed information of TA system TA168197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1227864..1228444
• Replicon: chromosome
• Accession: NZ_CP059060
• Organism: Synechococcus sp. LTW-R

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: H0O22_RS06955
• Protein ID: WP_185188351.1
• Coordinates: 1227864..1228091 (+)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: H0O22_RS06960
• Protein ID: WP_185186018.1
• Coordinates: 1228115..1228444 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0O22_RS06935	1223327..1225393	+	2067	WP_185186014.1	PBP1A family penicillin-binding protein	-
H0O22_RS06940	1225390..1226715	-	1326	WP_185186015.1	16S rRNA (cytosine(967)-C(5))-methyltransferase	-
H0O22_RS06945	1226712..1227044	-	333	WP_185186016.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
H0O22_RS06950	1227095..1227790	+	696	WP_185186017.1	tRNA (guanosine(18)-2'-O)-methyltransferase TrmH	-
H0O22_RS06955	1227864..1228091	+	228	WP_185188351.1	type II toxin-antitoxin system HicA family toxin	Toxin
H0O22_RS06960	1228115..1228444	+	330	WP_185186018.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H0O22_RS06965	1228448..1229272	-	825	WP_185186019.1	ABC transporter permease	-
H0O22_RS06970	1229368..1230081	+	714	WP_185186020.1	response regulator transcription factor	-
H0O22_RS06975	1230078..1230326	+	249	WP_185186021.1	hypothetical protein	-
H0O22_RS06980	1230323..1231045	+	723	WP_185186022.1	peptidylprolyl isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-73)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8538.75 Da
• Isoelectric Point: 11.5412

>T168197 WP_185188351.1 NZ_CP059060:1227864-1228091 [Synechococcus sp. LTW-R]
MRRRHRRTLELIYSRPVSGSVPWRDIEALFQELGGEISERAGSRVAVVLFGEIRVFHRPHTSPDTDKGAVAAIRQ

Nucleotide

• Length: 228 bp

>T168197 NZ_CP075653:39058-39444 [Escherichia coli]
ATGAAATTCGTTAGTTCACAGGAAATGATTGAGTTTCATGACCGCTTGATTTCGCGTGATGGTGGCGTGGCGGGTATGCC
AGAACCCGGTCGCGCTGACGCGATCATTCATCGTGTTTTGAACATGTATCATTATGAAGGTGTGACAGATATTATGGATC
TGGCTGCCGTGTATTTAGTTGCTATTGCTCGTGGTCACATTTTCAACGATGCAAATAAGCGAACAGCCTTGTTTGTTGCA
CAGGTTTTTTTAAAACGGAATGGTATACATATTATTAGTTCGCGTATTTCGTTTGATGAAATGCAAATTATCGCTTTGAA
TGCTGCAACAGGAGAATATAACTGGAAGATGGTTTCTGACCATCTTAAAGCCATTATTTTAAATTAG

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12322.87 Da
• Isoelectric Point: 5.2185

>AT168197 WP_185186018.1 NZ_CP059060:1228115-1228444 [Synechococcus sp. LTW-R]
MTLMSLDGYQARITYNPESDQFRGEILGQSGGAEFYGSNPDELRREFKQSLEVYLEVCRERGIAPRKQFSGKFNLRIPPD
LHEQLSLEAEAQGKSLNVLAKEALQKSLS

Nucleotide

• Length: 330 bp

>AT168197 NZ_CP075653:38837-39061 [Escherichia coli]
ATGTTTACATGTAACTATAGCCATGCTCGCGATAACCTGGCCTCGTTGCTCGAGCTGGCGGTTGATGAAAATCAGCCTGT
TGAGATTCAGCGCCGTAAAGGTGGCGCGGCTGTACTGGTTGATAAAGACGCTTTTGAACGATACCGTAAAGCGGCTCTTG
ATGCTGAGTTTGCTGAGATCATGCAAAGTCATGGGACGGCCTATACGGAGCTTTCTAAGCGATGA