Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1227864..1228444 Replicon chromosome
Accession NZ_CP059060
Organism Synechococcus sp. LTW-R

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H0O22_RS06955 Protein ID WP_185188351.1
Coordinates 1227864..1228091 (+) Length 76 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H0O22_RS06960 Protein ID WP_185186018.1
Coordinates 1228115..1228444 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0O22_RS06935 1223327..1225393 + 2067 WP_185186014.1 PBP1A family penicillin-binding protein -
H0O22_RS06940 1225390..1226715 - 1326 WP_185186015.1 16S rRNA (cytosine(967)-C(5))-methyltransferase -
H0O22_RS06945 1226712..1227044 - 333 WP_185186016.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
H0O22_RS06950 1227095..1227790 + 696 WP_185186017.1 tRNA (guanosine(18)-2'-O)-methyltransferase TrmH -
H0O22_RS06955 1227864..1228091 + 228 WP_185188351.1 type II toxin-antitoxin system HicA family toxin Toxin
H0O22_RS06960 1228115..1228444 + 330 WP_185186018.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H0O22_RS06965 1228448..1229272 - 825 WP_185186019.1 ABC transporter permease -
H0O22_RS06970 1229368..1230081 + 714 WP_185186020.1 response regulator transcription factor -
H0O22_RS06975 1230078..1230326 + 249 WP_185186021.1 hypothetical protein -
H0O22_RS06980 1230323..1231045 + 723 WP_185186022.1 peptidylprolyl isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-73)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8538.75 Da        Isoelectric Point: 11.5412

>T168197 WP_185188351.1 NZ_CP059060:1227864-1228091 [Synechococcus sp. LTW-R]
MRRRHRRTLELIYSRPVSGSVPWRDIEALFQELGGEISERAGSRVAVVLFGEIRVFHRPHTSPDTDKGAVAAIRQ

Download         Length: 228 bp

>T168197 NZ_CP075653:39058-39444 [Escherichia coli]
ATGAAATTCGTTAGTTCACAGGAAATGATTGAGTTTCATGACCGCTTGATTTCGCGTGATGGTGGCGTGGCGGGTATGCC
AGAACCCGGTCGCGCTGACGCGATCATTCATCGTGTTTTGAACATGTATCATTATGAAGGTGTGACAGATATTATGGATC
TGGCTGCCGTGTATTTAGTTGCTATTGCTCGTGGTCACATTTTCAACGATGCAAATAAGCGAACAGCCTTGTTTGTTGCA
CAGGTTTTTTTAAAACGGAATGGTATACATATTATTAGTTCGCGTATTTCGTTTGATGAAATGCAAATTATCGCTTTGAA
TGCTGCAACAGGAGAATATAACTGGAAGATGGTTTCTGACCATCTTAAAGCCATTATTTTAAATTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12322.87 Da        Isoelectric Point: 5.2185

>AT168197 WP_185186018.1 NZ_CP059060:1228115-1228444 [Synechococcus sp. LTW-R]
MTLMSLDGYQARITYNPESDQFRGEILGQSGGAEFYGSNPDELRREFKQSLEVYLEVCRERGIAPRKQFSGKFNLRIPPD
LHEQLSLEAEAQGKSLNVLAKEALQKSLS

Download         Length: 330 bp

>AT168197 NZ_CP075653:38837-39061 [Escherichia coli]
ATGTTTACATGTAACTATAGCCATGCTCGCGATAACCTGGCCTCGTTGCTCGAGCTGGCGGTTGATGAAAATCAGCCTGT
TGAGATTCAGCGCCGTAAAGGTGGCGCGGCTGTACTGGTTGATAAAGACGCTTTTGAACGATACCGTAAAGCGGCTCTTG
ATGCTGAGTTTGCTGAGATCATGCAAAGTCATGGGACGGCCTATACGGAGCTTTCTAAGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References