Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | PumAB/COG3657-DUF971 |
Location | 12843..13444 | Replicon | plasmid pBS1141 |
Accession | NZ_CP059053 | ||
Organism | Pseudomonas putida strain BS3701 |
Toxin (Protein)
Gene name | PumA | Uniprot ID | Q8VMN7 |
Locus tag | H0H12_RS28960 | Protein ID | WP_011005862.1 |
Coordinates | 13142..13444 (-) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | PumB | Uniprot ID | Q8VMN8 |
Locus tag | H0H12_RS28955 | Protein ID | WP_011005861.1 |
Coordinates | 12843..13145 (-) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H0H12_RS28930 | 8108..9394 | - | 1287 | WP_180690183.1 | Y-family DNA polymerase | - |
H0H12_RS28935 | 9384..9815 | - | 432 | WP_011005854.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
H0H12_RS28940 | 9953..10903 | + | 951 | WP_062378615.1 | non-homologous end-joining DNA ligase | - |
H0H12_RS28945 | 10934..11209 | + | 276 | WP_011005856.1 | hypothetical protein | - |
H0H12_RS28950 | 12578..12802 | - | 225 | WP_011005860.1 | hypothetical protein | - |
H0H12_RS28955 | 12843..13145 | - | 303 | WP_011005861.1 | putative addiction module antidote protein | Antitoxin |
H0H12_RS28960 | 13142..13444 | - | 303 | WP_011005862.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
H0H12_RS28965 | 13646..14425 | + | 780 | WP_180690184.1 | DUF4942 domain-containing protein | - |
H0H12_RS28970 | 14579..14947 | + | 369 | WP_011005864.1 | hypothetical protein | - |
H0H12_RS28975 | 14980..15297 | + | 318 | WP_062378618.1 | hypothetical protein | - |
H0H12_RS28980 | 15353..15571 | + | 219 | WP_011005866.1 | hypothetical protein | - |
H0H12_RS28985 | 15710..16729 | + | 1020 | WP_062378625.1 | hypothetical protein | - |
H0H12_RS28990 | 16872..17114 | + | 243 | WP_011005868.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..107388 | 107388 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 14882.85 Da Isoelectric Point: 5.5500
>T168191 WP_011005862.1 NZ_CP059053:c13444-13142 [Pseudomonas putida]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF
Download Length: 303 bp
>T168191 NZ_CP075652:3664205-3664612 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 14882.85 Da Isoelectric Point: 5.5500
>AT168191 WP_011005861.1 NZ_CP059053:c13145-12843 [Pseudomonas putida]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF
Download Length: 303 bp
>AT168191 NZ_CP075652:3663958-3664224 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2K4KM11 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q8VMN8 |