Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4619744..4620401 Replicon chromosome
Accession NZ_CP059047
Organism Raoultella ornithinolytica strain DSM 16926

Toxin (Protein)


Gene name cptA Uniprot ID A0A808XTM6
Locus tag HYH04_RS21500 Protein ID WP_004867355.1
Coordinates 4619991..4620401 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A514ELX1
Locus tag HYH04_RS21495 Protein ID WP_004867358.1
Coordinates 4619744..4620010 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYH04_RS21470 4614879..4616312 - 1434 WP_015585781.1 6-phospho-beta-glucosidase -
HYH04_RS21475 4616432..4617160 - 729 WP_015585782.1 MurR/RpiR family transcriptional regulator -
HYH04_RS21480 4617210..4617521 + 312 WP_004867365.1 N(4)-acetylcytidine aminohydrolase -
HYH04_RS21485 4617683..4618342 + 660 WP_004867362.1 hemolysin III family protein -
HYH04_RS21490 4618464..4619447 - 984 WP_015585783.1 tRNA-modifying protein YgfZ -
HYH04_RS21495 4619744..4620010 + 267 WP_004867358.1 FAD assembly factor SdhE Antitoxin
HYH04_RS21500 4619991..4620401 + 411 WP_004867355.1 protein YgfX Toxin
HYH04_RS21505 4620409..4620930 - 522 WP_004867353.1 flavodoxin FldB -
HYH04_RS21510 4621108..4622004 + 897 WP_015585784.1 site-specific tyrosine recombinase XerD -
HYH04_RS21515 4622027..4622740 + 714 WP_004867349.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HYH04_RS21520 4622746..4624479 + 1734 WP_015585785.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16226.16 Da        Isoelectric Point: 11.3349

>T168189 WP_004867355.1 NZ_CP059047:4619991-4620401 [Raoultella ornithinolytica]
VVLWQSDLRISWRSQWFSLLLHGIVAAIVLLMPWPLSYTPLWLLLLSLVVFDSVRSQRRIHACRGEIKLMTDSRLRWQKA
EWEIVGTPWVINSGMLLRLQDMQTRRRQHLWIAADSMDAKEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T168189 NZ_CP075652:c3345688-3345224 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10553.05 Da        Isoelectric Point: 4.8432

>AT168189 WP_004867358.1 NZ_CP059047:4619744-4620010 [Raoultella ornithinolytica]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKQLFIRLLENDDPDLFNWLMNHGEPADAQLQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT168189 NZ_CP075652:c3346023-3345688 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCTCGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808XTM6

Antitoxin

Source ID Structure
AlphaFold DB A0A514ELX1

References