Detailed information of TA system TA168183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 802001..802914
• Replicon: chromosome
• Accession: NZ_CP059047
• Organism: Raoultella ornithinolytica strain DSM 16926

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HYH04_RS03625
• Protein ID: WP_180553820.1
• Coordinates: 802001..802474 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HYH04_RS03630
• Protein ID: WP_032716402.1
• Coordinates: 802471..802914 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYH04_RS03600	798040..798648	-	609	WP_180553816.1	glutathione S-transferase family protein	-
HYH04_RS03605	798890..799795	+	906	WP_032716408.1	transcriptional regulator GcvA	-
HYH04_RS03610	799823..800728	-	906	WP_004862787.1	LysR family transcriptional regulator	-
HYH04_RS03615	800831..801148	+	318	WP_180553818.1	nuclear transport factor 2 family protein	-
HYH04_RS03620	801141..801920	+	780	WP_088912307.1	SDR family oxidoreductase	-
HYH04_RS03625	802001..802474	-	474	WP_180553820.1	RES domain-containing protein	Toxin
HYH04_RS03630	802471..802914	-	444	WP_032716402.1	DUF2384 domain-containing protein	Antitoxin
HYH04_RS03635	803104..803670	-	567	WP_015584190.1	DJ-1/PfpI family protein	-
HYH04_RS03640	804068..804850	+	783	WP_032717546.1	DUF3750 domain-containing protein	-
HYH04_RS03645	805047..806270	+	1224	WP_069475891.1	zinc metallochaperone GTPase ZigA	-
HYH04_RS03665	807200..807676	-	477	WP_071887178.1	acid resistance repetitive basic protein Asr	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (95-144)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17582.86 Da
• Isoelectric Point: 4.6340

>T168183 WP_180553820.1 NZ_CP059047:c802474-802001 [Raoultella ornithinolytica]
MIFYRLVTGRYASEAWTGSGANQYGGRWNHQGHPAVYVSTSIALASLEILVHVKNEAILNQYQLYSIEIPDSEVESLDKQ
WLPDNWQENPMPVSTMDLGTGWLQSDSGLALMLPSCIIPYENNAILNPLHPAFSEALASVRQYPFTFDPRLARSTPL

Nucleotide

• Length: 474 bp

>T168183 NZ_CP075652:1890289-1890441 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16176.42 Da
• Isoelectric Point: 4.9405

>AT168183 WP_032716402.1 NZ_CP059047:c802914-802471 [Raoultella ornithinolytica]
MKTWVPAEQPADNALWRYAGLPANRGMQLIELLSMGLPVSVLDNIHEWTEMSKTDILRITGINERNVARRKSAGGTLTPG
ESERVARFVRVLDTAVDYFGSKQDAYDWLQSPVRGLGNVAPIDLIATESGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT168183 NZ_CP075652:c1890240-1890183 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA