Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3646209..3646728 Replicon chromosome
Accession NZ_CP059045
Organism Cronobacter sakazakii strain 5563_17

Toxin (Protein)


Gene name relE Uniprot ID A0A6L3SA96
Locus tag HZZ03_RS16960 Protein ID WP_012123737.1
Coordinates 3646209..3646496 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6L3PAY9
Locus tag HZZ03_RS16965 Protein ID WP_012123736.1
Coordinates 3646486..3646728 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZZ03_RS16940 3641495..3642025 - 531 WP_012123740.1 NAD(P)H-dependent oxidoreductase -
HZZ03_RS16945 3642128..3643009 + 882 WP_012123739.1 LysR family transcriptional regulator -
HZZ03_RS16950 3643306..3645441 + 2136 WP_012123738.1 anaerobic ribonucleoside-triphosphate reductase -
HZZ03_RS16955 3645737..3646201 + 465 WP_007897806.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HZZ03_RS16960 3646209..3646496 - 288 WP_012123737.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZZ03_RS16965 3646486..3646728 - 243 WP_012123736.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HZZ03_RS16970 3646806..3648716 - 1911 WP_012123735.1 BglG family transcription antiterminator -
HZZ03_RS16975 3648830..3649570 - 741 WP_097569936.1 KDGP aldolase family protein -
HZZ03_RS16980 3649567..3650685 - 1119 WP_014728026.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10839.85 Da        Isoelectric Point: 10.5836

>T168173 WP_012123737.1 NZ_CP059045:c3646496-3646209 [Cronobacter sakazakii]
MSYKLVFDPRALKEWHKLGETVKAQFKKKLAHVLAAPRVKSVRLSGLPDCYKIKLRTSGYRLVYQVRDDAVCVLVIAIGK
RENLTVYQGAGHRLE

Download         Length: 288 bp

>T168173 NZ_CP075649:c4957427-4957116 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9068.47 Da        Isoelectric Point: 5.1088

>AT168173 WP_012123736.1 NZ_CP059045:c3646728-3646486 [Cronobacter sakazakii]
MATINVRLDDKLKNEAYAVLEKLGITPTEAVRLLFQYVAQNGRMPVKTLTVSDSEEALLRTVRERLADPRQGIRVDLDEL

Download         Length: 243 bp

>AT168173 NZ_CP075649:c4957115-4956825 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L3SA96

Antitoxin

Source ID Structure
AlphaFold DB A0A6L3PAY9

References