Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3453935..3454598 Replicon chromosome
Accession NZ_CP059045
Organism Cronobacter sakazakii strain 5563_17

Toxin (Protein)


Gene name cptA Uniprot ID A0A6L3S892
Locus tag HZZ03_RS16090 Protein ID WP_012123856.1
Coordinates 3453935..3454351 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3Q9CFW7
Locus tag HZZ03_RS16095 Protein ID WP_007870701.1
Coordinates 3454332..3454598 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZZ03_RS16070 3449923..3451656 - 1734 WP_041460381.1 single-stranded-DNA-specific exonuclease RecJ -
HZZ03_RS16075 3451660..3452379 - 720 WP_004385678.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HZZ03_RS16080 3452402..3453298 - 897 WP_004385677.1 site-specific tyrosine recombinase XerD -
HZZ03_RS16085 3453400..3453921 + 522 WP_004385676.1 flavodoxin FldB -
HZZ03_RS16090 3453935..3454351 - 417 WP_012123856.1 protein YgfX Toxin
HZZ03_RS16095 3454332..3454598 - 267 WP_007870701.1 FAD assembly factor SdhE Antitoxin
HZZ03_RS16100 3454876..3455865 + 990 WP_007870703.1 tRNA-modifying protein YgfZ -
HZZ03_RS16105 3455970..3456623 - 654 WP_007777939.1 hemolysin III family protein -
HZZ03_RS16110 3456766..3457080 - 315 WP_012123853.1 N(4)-acetylcytidine aminohydrolase -
HZZ03_RS16115 3457257..3457985 + 729 WP_180552886.1 MurR/RpiR family transcriptional regulator -
HZZ03_RS16120 3458137..3459570 + 1434 WP_012123851.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16467.47 Da        Isoelectric Point: 11.2099

>T168172 WP_012123856.1 NZ_CP059045:c3454351-3453935 [Cronobacter sakazakii]
VVLWHSDLRVSWRSQWLSLLLHGAVAVIILLLPWPLRYLPVWMLLLSLVVFDCVRSQRRINAFQGEVSLTADYYLRWQGV
DWQICATPWMLRSGMMLRLRHPKTTRRHHVWLAADSMTEAEWRDLRRLLLQQPVGDKR

Download         Length: 417 bp

>T168172 NZ_CP075649:c4680339-4680166 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.89 Da        Isoelectric Point: 4.8310

>AT168172 WP_007870701.1 NZ_CP059045:c3454598-3454332 [Cronobacter sakazakii]
MDINNKARIHWACRRGMRELDISIMPFFEYDYDSLSDEDKRVFVRLLECDDPDLFNWLMNHGKPADAELARMVELIQQRN
QARGPVAL

Download         Length: 267 bp

>AT168172 NZ_CP075649:c4680663-4680367 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L3S892

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q9CFW7

References