168108

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 4537..5125 Replicon plasmid unnamed
Accession NZ_CP059042
Organism Acinetobacter baumannii strain ATCC 17978

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag H0N28_RS19135 Protein ID WP_000438826.1
Coordinates 4537..4824 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID A0A858UV00
Locus tag H0N28_RS19140 Protein ID WP_061855757.1
Coordinates 4811..5125 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0N28_RS19100 1..576 + 576 WP_001096616.1 helix-turn-helix domain-containing protein -
H0N28_RS19105 596..739 + 144 WP_001125244.1 hypothetical protein -
H0N28_RS19110 924..1127 - 204 WP_000482656.1 hypothetical protein -
H0N28_RS19115 1371..1616 + 246 WP_000246756.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
H0N28_RS19120 1606..1899 + 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin -
H0N28_RS19125 2117..3319 + 1203 WP_061855756.1 alpha/beta fold hydrolase -
H0N28_RS19130 3417..4190 + 774 WP_061855758.1 glucose 1-dehydrogenase -
H0N28_RS19135 4537..4824 + 288 WP_000438826.1 BrnT family toxin Toxin
H0N28_RS19140 4811..5125 + 315 WP_061855757.1 BrnA antitoxin family protein Antitoxin
H0N28_RS19145 5254..7664 + 2411 Protein_10 TonB-dependent receptor -
H0N28_RS19150 7761..8459 + 699 WP_000007662.1 CPBP family intramembrane metalloprotease -
H0N28_RS19155 8581..8778 - 198 WP_001282483.1 hypothetical protein -
H0N28_RS19160 8795..9407 + 613 Protein_13 SDR family oxidoreductase -
H0N28_RS19165 9738..10036 + 299 Protein_14 BrnT family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..16502 16502


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T168108 WP_000438826.1 NZ_CP059042:4537-4824 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T168108 NZ_CP075633:59619-60035 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12227.88 Da        Isoelectric Point: 8.4628

>AT168108 WP_061855757.1 NZ_CP059042:4811-5125 [Acinetobacter baumannii]
MSMVRYSRKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT168108 NZ_CP075633:59392-59622 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB A0A858UV00

References