Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1371..1899 Replicon plasmid unnamed
Accession NZ_CP059042
Organism Acinetobacter baumannii strain ATCC 17978

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag H0N28_RS19120 Protein ID WP_000221358.1
Coordinates 1606..1899 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9B5Q7
Locus tag H0N28_RS19115 Protein ID WP_000246756.1
Coordinates 1371..1616 (+) Length 82 a.a.

Genomic Context

H0N28_RS19100H0N28_RS19105H0N28_RS19115H0N28_RS19120H0N28_RS19125H0N28_RS19130H0N28_RS19135H0N28_RS19140H0N28_RS19110
Location: 1..576 (576 bp)
Type: Others
Protein ID: WP_001096616.1
Location: 596..739 (144 bp)
Type: Others
Protein ID: WP_001125244.1
Location: 1371..1616 (246 bp)
Type: Antitoxin
Protein ID: WP_000246756.1
Location: 1606..1899 (294 bp)
Type: Toxin
Protein ID: WP_000221358.1
Location: 2117..3319 (1203 bp)
Type: Others
Protein ID: WP_061855756.1
Location: 3417..4190 (774 bp)
Type: Others
Protein ID: WP_061855758.1
Location: 4537..4824 (288 bp)
Type: Others
Protein ID: WP_000438826.1
Location: 4811..5125 (315 bp)
Type: Others
Protein ID: WP_061855757.1
Location: 924..1127 (204 bp)
Type: Others
Protein ID: WP_000482656.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
H0N28_RS191001..576+576WP_001096616.1helix-turn-helix domain-containing protein-
H0N28_RS19105596..739+144WP_001125244.1hypothetical protein-
H0N28_RS19110924..1127-204WP_000482656.1hypothetical protein-
H0N28_RS191151371..1616+246WP_000246756.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
H0N28_RS191201606..1899+294WP_000221358.1type II toxin-antitoxin system RelE/ParE family toxinToxin
H0N28_RS191252117..3319+1203WP_061855756.1alpha/beta fold hydrolase-
H0N28_RS191303417..4190+774WP_061855758.1glucose 1-dehydrogenase-
H0N28_RS191354537..4824+288WP_000438826.1BrnT family toxin-
H0N28_RS191404811..5125+315WP_061855757.1BrnA antitoxin family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..1650216502


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-71)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T168107 WP_000221358.1 NZ_CP059042:1606-1899 [Acinetobacter baumannii]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T168107 NZ_CP075633:c12173-11787 [Escherichia coli]
ATGAAATTCGTTAGTTCACAGGAAATGATTGAGTTTCATGACCGCTTGATTTCGCGTGATGGTGGCGTGGCGGGTATGCC
AGAACCCGGTCGCGCTGACGCGATCATTCATCGTGTTTTGAACATGTATCATTATGAAGGTGTGACAGATATTATGGATC
TGGCTGCCGTGTATTTAGTTGCTATTGCTCGTGGTCACATTTTCAACGATGCAAATAAGCGAACAGCCTTGTTTGTTGCA
CAGGTTTTTTTAAAACGGAATGGTATACATATTATTAGTTCGCGTATTTCGTTTGATGAAATGCAAATTATCGCTTTGAA
TGCTGCAACAGGAGAATATAACTGGAAGATGGTTTCTGACCATCTTAAAGCCATTATTTTAAATTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9235.61 Da        Isoelectric Point: 4.3142

>AT168107 WP_000246756.1 NZ_CP059042:1371-1616 [Acinetobacter baumannii]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT168107 NZ_CP075633:c12394-12170 [Escherichia coli]
ATGTTTACATGTAACTATAGCCATGCTCGCGATAACCTGGCCTCGTTGCTCGAGCTGGCGGTTGATGAAAATCAGCCTGT
TGAGATTCAGCGCCGTAAAGGTGGCGCGGCTGTACTGGTTGATAAAGACGCTTTTGAACGATACCGTAAAGCGGCTCTTG
ATGCTGAGTTTGCTGAGATCATGCAAAGTCATGGGACGGCCTATACGGAGCTTTCTAAGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A6A1RKP4

Antitoxin

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Source
ID
Structure
AlphaFold DBN9B5Q7

References