Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1371..1899 Replicon plasmid unnamed
Accession NZ_CP059042
Organism Acinetobacter baumannii strain ATCC 17978

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag H0N28_RS19120 Protein ID WP_000221358.1
Coordinates 1606..1899 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9B5Q7
Locus tag H0N28_RS19115 Protein ID WP_000246756.1
Coordinates 1371..1616 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0N28_RS19100 1..576 + 576 WP_001096616.1 helix-turn-helix domain-containing protein -
H0N28_RS19105 596..739 + 144 WP_001125244.1 hypothetical protein -
H0N28_RS19110 924..1127 - 204 WP_000482656.1 hypothetical protein -
H0N28_RS19115 1371..1616 + 246 WP_000246756.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H0N28_RS19120 1606..1899 + 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H0N28_RS19125 2117..3319 + 1203 WP_061855756.1 alpha/beta fold hydrolase -
H0N28_RS19130 3417..4190 + 774 WP_061855758.1 glucose 1-dehydrogenase -
H0N28_RS19135 4537..4824 + 288 WP_000438826.1 BrnT family toxin -
H0N28_RS19140 4811..5125 + 315 WP_061855757.1 BrnA antitoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..16502 16502


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-71)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T168107 WP_000221358.1 NZ_CP059042:1606-1899 [Acinetobacter baumannii]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T168107 NZ_CP075633:c12173-11787 [Escherichia coli]
ATGAAATTCGTTAGTTCACAGGAAATGATTGAGTTTCATGACCGCTTGATTTCGCGTGATGGTGGCGTGGCGGGTATGCC
AGAACCCGGTCGCGCTGACGCGATCATTCATCGTGTTTTGAACATGTATCATTATGAAGGTGTGACAGATATTATGGATC
TGGCTGCCGTGTATTTAGTTGCTATTGCTCGTGGTCACATTTTCAACGATGCAAATAAGCGAACAGCCTTGTTTGTTGCA
CAGGTTTTTTTAAAACGGAATGGTATACATATTATTAGTTCGCGTATTTCGTTTGATGAAATGCAAATTATCGCTTTGAA
TGCTGCAACAGGAGAATATAACTGGAAGATGGTTTCTGACCATCTTAAAGCCATTATTTTAAATTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9235.61 Da        Isoelectric Point: 4.3142

>AT168107 WP_000246756.1 NZ_CP059042:1371-1616 [Acinetobacter baumannii]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT168107 NZ_CP075633:c12394-12170 [Escherichia coli]
ATGTTTACATGTAACTATAGCCATGCTCGCGATAACCTGGCCTCGTTGCTCGAGCTGGCGGTTGATGAAAATCAGCCTGT
TGAGATTCAGCGCCGTAAAGGTGGCGCGGCTGTACTGGTTGATAAAGACGCTTTTGAACGATACCGTAAAGCGGCTCTTG
ATGCTGAGTTTGCTGAGATCATGCAAAGTCATGGGACGGCCTATACGGAGCTTTCTAAGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB N9B5Q7

References